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5jic

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==Staphylococcus aureus Type II pantothenate kinase in complex with a pantothenate analog==
==Staphylococcus aureus Type II pantothenate kinase in complex with a pantothenate analog==
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<StructureSection load='5jic' size='340' side='right' caption='[[5jic]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='5jic' size='340' side='right'caption='[[5jic]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jic]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JIC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jic]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JIC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N7E:N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-N-(5-METHOXYPENTYL)-BETA-ALANINAMIDE'>N7E</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N7E:N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-N-(5-METHOXYPENTYL)-BETA-ALANINAMIDE'>N7E</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jic OCA], [http://pdbe.org/5jic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jic RCSB], [http://www.ebi.ac.uk/pdbsum/5jic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jic ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jic OCA], [https://pdbe.org/5jic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jic RCSB], [https://www.ebi.ac.uk/pdbsum/5jic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jic ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/COAW_STAAW COAW_STAAW]] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity).
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[https://www.uniprot.org/uniprot/COAW_STAA8 COAW_STAA8] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:12760898</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jic" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jic" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pantothenate kinase]]
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[[Category: Large Structures]]
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[[Category: Antoshchenko, T]]
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[[Category: Staphylococcus aureus subsp. aureus MW2]]
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[[Category: Barnard, L]]
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[[Category: Antoshchenko T]]
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[[Category: Hughes, S J]]
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[[Category: Barnard L]]
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[[Category: Mottaghi, K]]
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[[Category: Hughes SJ]]
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[[Category: Park, H]]
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[[Category: Mottaghi K]]
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[[Category: Strauss, E]]
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[[Category: Park H]]
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[[Category: Antimicrobial]]
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[[Category: Strauss E]]
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[[Category: Inhibitor]]
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[[Category: Pantothenamide]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Staphylococcus aureus Type II pantothenate kinase in complex with a pantothenate analog

PDB ID 5jic

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