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5lof

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==Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1==
==Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1==
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<StructureSection load='5lof' size='340' side='right' caption='[[5lof]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5lof' size='340' side='right'caption='[[5lof]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lof]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LOF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=70R:(2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic+acid'>70R</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lof OCA], [http://pdbe.org/5lof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lof RCSB], [http://www.ebi.ac.uk/pdbsum/5lof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lof ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=70R:(2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic+acid'>70R</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lof OCA], [https://pdbe.org/5lof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lof RCSB], [https://www.ebi.ac.uk/pdbsum/5lof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lof ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
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[https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5lof" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lof" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Balint, B]]
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[[Category: Escherichia coli O157:H7]]
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[[Category: Blasko, G]]
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[[Category: Homo sapiens]]
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[[Category: Chen, I]]
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[[Category: Large Structures]]
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[[Category: Csekei, M]]
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[[Category: Balint B]]
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[[Category: Davidson, J]]
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[[Category: Blasko G]]
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[[Category: Dokurno, P]]
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[[Category: Chen I]]
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[[Category: Geneste, O]]
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[[Category: Csekei M]]
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[[Category: Graham, C]]
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[[Category: Davidson J]]
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[[Category: Kotschy, A]]
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[[Category: Dokurno P]]
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[[Category: Matassova, N]]
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[[Category: Geneste O]]
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[[Category: Murray, J]]
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[[Category: Graham C]]
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[[Category: Ondi, L]]
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[[Category: Kotschy A]]
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[[Category: Paczal, A]]
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[[Category: Matassova N]]
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[[Category: Pedder, C]]
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[[Category: Murray J]]
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[[Category: Proszenyak, A]]
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[[Category: Ondi L]]
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[[Category: Radics, G]]
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[[Category: Paczal A]]
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[[Category: Robertson, A]]
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[[Category: Pedder C]]
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[[Category: Sipos, S]]
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[[Category: Proszenyak A]]
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[[Category: Smith, J]]
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[[Category: Radics G]]
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[[Category: Surgenor, A]]
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[[Category: Robertson A]]
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[[Category: Szabo, Z]]
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[[Category: Sipos S]]
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[[Category: Szlavik, Z]]
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[[Category: Smith J]]
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[[Category: Apoptosis-inhibitor complex]]
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[[Category: Surgenor A]]
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[[Category: Mbp]]
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[[Category: Szabo Z]]
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[[Category: Mcl-1]]
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[[Category: Szlavik Z]]
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[[Category: S s63845]]
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Current revision

Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1

PDB ID 5lof

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