5to0

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'''Unreleased structure'''
 
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The entry 5to0 is ON HOLD until Paper Publication
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==HTRA2 S276C mutant==
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<StructureSection load='5to0' size='340' side='right'caption='[[5to0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5to0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TO0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5to0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5to0 OCA], [https://pdbe.org/5to0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5to0 RCSB], [https://www.ebi.ac.uk/pdbsum/5to0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5to0 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HTRA2_HUMAN HTRA2_HUMAN] Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:[https://omim.org/entry/610297 610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.<ref>PMID:15961413</ref> <ref>PMID:18401856</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HTRA2_HUMAN HTRA2_HUMAN] Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.<ref>PMID:15200957</ref> <ref>PMID:19502560</ref>
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Authors: Merski, M., Barbosa Pereira, P.J., Macedo-Ribeiro, S.
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==See Also==
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*[[Proteinase 3D structures|Proteinase 3D structures]]
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Description: HTRA2 S276C mutant
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Merski, M]]
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__TOC__
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[[Category: Macedo-Ribeiro, S]]
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</StructureSection>
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[[Category: Barbosa Pereira, P.J]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Barbosa Pereira PJ]]
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[[Category: Macedo-Ribeiro S]]
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[[Category: Merski M]]

Current revision

HTRA2 S276C mutant

PDB ID 5to0

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