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5b73

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==Crystal structure of human ZMYND8 PHD-Bromo-PWWP domain==
==Crystal structure of human ZMYND8 PHD-Bromo-PWWP domain==
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<StructureSection load='5b73' size='340' side='right' caption='[[5b73]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5b73' size='340' side='right'caption='[[5b73]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5b73]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B73 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5b73]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B73 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b73 OCA], [http://pdbe.org/5b73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b73 RCSB], [http://www.ebi.ac.uk/pdbsum/5b73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b73 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b73 OCA], [https://pdbe.org/5b73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b73 RCSB], [https://www.ebi.ac.uk/pdbsum/5b73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b73 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/PKCB1_HUMAN PKCB1_HUMAN]
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Histone acetylation, including acetylated H3K14 (H3K14ac), is generally linked to gene activation. Monomethylated histone H3 lysine 4 (H3K4me1), together with other gene-activating marks, denotes active genes. In contrast to usual gene-activating functions of H3K14ac and H3K4me1, we here show that the dual histone modification mark H3K4me1-H3K14ac is recognized by ZMYND8 (also called RACK7) and can function to counteract gene expression. We identified ZMYND8 as a transcriptional corepressor of the H3K4 demethylase JARID1D. ZMYND8 antagonized the expression of metastasis-linked genes, and its knockdown increased the cellular invasiveness in vitro and in vivo. The plant homeodomain (PHD) and Bromodomain cassette in ZMYND8 mediated the combinatorial recognition of H3K4me1-H3K14ac and H3K4me0-H3K14ac by ZMYND8. These findings uncover an unexpected role for the signature H3K4me1-H3K14ac in attenuating gene expression and reveal a metastasis-suppressive epigenetic mechanism in which ZMYND8's PHD-Bromo cassette couples H3K4me1-H3K14ac with downregulation of metastasis-linked genes.
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ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.,Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen TY, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG Mol Cell. 2016 Aug 4;63(3):470-84. doi: 10.1016/j.molcel.2016.06.035. Epub 2016, Jul 28. PMID:27477906<ref>PMID:27477906</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5b73" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Li, H]]
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[[Category: Homo sapiens]]
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[[Category: Li, Y]]
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[[Category: Large Structures]]
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[[Category: Zheng, X]]
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[[Category: Li H]]
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[[Category: Metal binding protein]]
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[[Category: Li Y]]
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[[Category: Zinc finger protein]]
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[[Category: Zheng X]]

Current revision

Crystal structure of human ZMYND8 PHD-Bromo-PWWP domain

PDB ID 5b73

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