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Aldose Reductase
From Proteopedia
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| - | <StructureSection load='1ads' size=' | + | <StructureSection load='1ads' size='400' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/ | + | AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/8'>active site is located in the barrel core</scene>.<ref>PMID:1621098</ref> |
| + | *<scene name='43/436098/Cv/7'>Active site interactions</scene>. Water molecules are shown as red spheres. | ||
| + | *<scene name='43/436098/Cv/9'>Active site tunnel</scene>. | ||
| + | |||
| + | == 3D Structures of aldose reductase == | ||
| + | [[Aldose reductase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Aldose Reductase == | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *Aldose Reductase | ||
| - | |||
| - | **[[1abn]], [[1ads]], [[3q65]] - hAldR +NADP – human<br /> | ||
| - | **[[2alr]] – hAldR <br /> | ||
| - | **[[1xgd]] – hAldR (mutant)<br /> | ||
| - | **[[3q67]] – hAldR (mutant)+NADP<br /> | ||
| - | **[[3afm]] – SsAldR A1-R – ''Sphingomonas sp.''<br /> | ||
| - | **[[3afn]] - SsAldR A1-R+NADP<br /> | ||
| - | **[[1dla]], [[1cwn]] – pAldR - pig<br /> | ||
| - | **[[1ah4]], [[3cv7]] - pAldR+NADP<br /> | ||
| - | **[[1hqt]] – pAldR (mutant) + NADP<br /> | ||
| - | **[[3krb]] – AldR+NADP – ''Ghiardia lamblia''<br /> | ||
| - | **[[2bgq]] – bAldR - barley<br /> | ||
| - | **[[2bgs]] - bAldR+NADP<br /> | ||
| - | **[[4gca]] – AldR – mouse<br /> | ||
| - | **[[4hbk]] – AldR – ''Schistosoma japonicum''<br /> | ||
| - | |||
| - | *Aldose Reductase+inhibitors | ||
| - | **[[3ghr]], [[3ghs]], [[3ght]], [[3ghu]], [[2r24]], [[2pzn]], [[3g5e]], [[2qxw]], [[2iki]], [[2i16]], [[2i17]], [[1t40]], [[1t41]], [[1us0]], [[1el3]], [[3t42]] - hAldR +NADP+IDD inhibitors<br /> | ||
| - | **[[3onb]], [[3onc]] – hAldR (mutant) +NADP+IDD inhibitor<br /> | ||
| - | **[[3u2c]] - hAldR +NADP+ NSAID inhibitor<br /> | ||
| - | **[[3bcj]], [[1x97]], [[1x98]], [[1pwm]], [[1ef3]], [[2pd5]], [[2dux]], [[2duz]], [[2dv0]], [[2fz8]], [[2fz9]], [[2hv5]], [[2hvn]], [[2hvo]], [[1mar]], [[2fzb]], [[2fzd]], [[1z3n]], [[1pwl]], [[1iei]], [[4jir]] - hAldR+NADP+inhibitor for diabetic treatment<br /> | ||
| - | **[[1z89]], [[1z8a]] - hAldR+NADP+sulfonyl-pyridazinone<br /> | ||
| - | **[[2pdg]], [[2pdh]] - hAldR+NADP+uracil inhibitor<br /> | ||
| - | **[[2j8t]], [[1x96]], [[2acs]], [[2acu]] - hAldR+NADP+citrate<br /> | ||
| - | **[[2acq]] - hAldR +NADP+glucose phosphate<br /> | ||
| - | **[[2acr]] - hAldR +NADP+cacodylate<br /> | ||
| - | **[[2ikg]], [[2ikh]], [[2ikj]], [[3v35]] - hAldR+NADP+nitro-substituted inhibitor<br /> | ||
| - | **[[3v36]] - hAldR+NADP+ glyceraldehyde + azine<br /> | ||
| - | **[[2nvc]], [[2nvd]] - hAldR+NADP+isothiazole inhibitor<br /> | ||
| - | **[[3p2v]] - hAldR+NADP+ benzothiazepine inhibitor<br /> | ||
| - | **[[2pev]], [[2pf8]], [[2pfh]] - hAldR+NADP+IDD inhibitor+ fidarestat<br /> | ||
| - | **[[2ipw]], [[2iq0]], [[2iqd]], [[2isf]], [[2ine]], [[2inz]], [[2is7]] - hAldR+NADP+ acid<br /> | ||
| - | **[[2f2k]] - hAldR+NADP+DEG<br /> | ||
| - | **[[2pdn]], [[2pdq]] – hAldR (mutant)+NADP+uracil inhibitor<br /> | ||
| - | **[[2pdb]], [[2pdf]], [[2pdi]], [[2pdm]], [[2pdx]], [[3len]], [[3m0i]], [[3mb9]], [[2pd9]], [[2pdw]], [[2pdy]], [[2agt]], [[2pdl]] – hAldR (mutant)+NADP+inhibitor for diabetic treatment<br /> | ||
| - | **[[2pdk]] - hAldR (mutant)+NADP+sorbinil<br /> | ||
| - | **[[1az1]] – hAldR (mutant)+NADP+alrestatin<br /> | ||
| - | **[[1az2]] - hAldR (mutant)+NADP+citrate<br /> | ||
| - | **[[3lbo]], [[3ld5]], [[3lql]], [[3lz5]], [[2pdc]], [[3lep]], [[3lqg]], [[3lz3]], [[3m4h]], [[2pdj]], [[2pdp]], [[2pdu]], [[3m64]], [[3mc5]] - hAldR (mutant)+IDD inhibitors<br /> | ||
| - | **[[3dn5]] – hAldR+NADP+biaryl inhibitor<br /> | ||
| - | **[[4gq0]] - hAldR+NADP+ phenol derivative<br /> | ||
| - | **[[3rx2]], [[3rx3]], [[3rx4]], [[3s3g]] - hAldR+NADP+ sulindac inhibitor<br /> | ||
| - | **[[4igs]] - hAldR+NADP+ polyfluorinated inhibitor<br /> | ||
| - | **[[4lau]], [[4laz]], [[4lb3]], [[4lb4]], [[4lbr]], [[4lbs]] - hAldR+NADP+ carbamoyl inhibitor<br /> | ||
| - | **[[3fx4]] – pAldR+NADP+thiazolidine derivative <br /> | ||
| - | **[[3h4g]] – pAldR+NADP+fidarestat<br /> | ||
| - | **[[1ah3]], [[1ae4]] - pAldR+NADP+tolrestat<br /> | ||
| - | **[[1ah0]] - pAldR+NADP+sorbinil<br /> | ||
| - | **[[1eko]] - pAldR+NADP+IDD inhibitor<br /> | ||
| - | **[[2vdg]] – bAldR+NADP+butanol <br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
- ↑ Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098
