Cholesterol oxidase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | There are predominantly hydrophobic/non-polar residues in <scene name='48/486379/Cv/ | + | There are predominantly hydrophobic/non-polar residues in <scene name='48/486379/Cv/7'>steroid substrate binding site</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}) in COX. <scene name='48/486379/Cv/8'>FAD binding site</scene> (PDB entry [[1coy]]).<ref>PMID:8218217</ref> Water molecules are shown as red spheres. <scene name='48/486379/Cv/9'>Whole active site</scene>. |
</StructureSection> | </StructureSection> | ||
==3D structure of cholesterol oxidase== | ==3D structure of cholesterol oxidase== | ||
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**[[3cox]], [[1i19]] – BsCOX – ''Brevibacterium sterolicum''<br /> | **[[3cox]], [[1i19]] – BsCOX – ''Brevibacterium sterolicum''<br /> | ||
| - | **[[1b4v]], [[1mxt]], [[1n1p]], [[1n4u]], [[1n4v]], [[1n4w]], [[2gew]], [[4u2l]], [[4u2s]], [[4u2t]] – StCOX – ''Streptomyces''<br /> | + | **[[1b4v]], [[1mxt]], [[1n1p]], [[1n4u]], [[1n4v]], [[1n4w]], [[2gew]], [[4u2l]], [[4u2s]], [[4u2t]], [[5kwf]], [[4xxg]], [[4xwr]], [[4rek]] – StCOX – ''Streptomyces''<br /> |
**[[1b8s]], [[1cbo]], [[1cc2]], [[1ijh]], [[3b6d]], [[3cnj]], [[3gyi]], [[3gyj]] – StCOX (mutant)<br /> | **[[1b8s]], [[1cbo]], [[1cc2]], [[1ijh]], [[3b6d]], [[3cnj]], [[3gyi]], [[3gyj]] – StCOX (mutant)<br /> | ||
**[[3js8]] – COX – ''Chromobacterium''<br /> | **[[3js8]] – COX – ''Chromobacterium''<br /> | ||
Current revision
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3D structure of cholesterol oxidase
Updated on 12-May-2019
References
- ↑ Sagermann M, Ohtaki A, Newton K, Doukyu N. Structural characterization of the organic solvent-stable cholesterol oxidase from Chromobacterium sp. DS-1. J Struct Biol. 2010 Apr;170(1):32-40. Epub 2010 Jan 25. PMID:20102741 doi:10.1016/j.jsb.2010.01.012
- ↑ Li J, Vrielink A, Brick P, Blow DM. Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases. Biochemistry. 1993 Nov 2;32(43):11507-15. PMID:8218217
