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Tryptophan RNA-binding attenuation protein

From Proteopedia

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<StructureSection load='2exs' size='340' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>
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<StructureSection load='2exs' size='350' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>
== Function ==
== Function ==
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'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP<ref>PMID:14687568</ref>.
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'''Tryptophan RNA-binding attenuation protein''' (TRAP) or '''transcription attenuation protein MtrB''' is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 tryptophan molecules to TRAP<ref>PMID:14687568</ref>.
== Structural highlights ==
== Structural highlights ==
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TRAP is composed of 11 identical subunits arranged in a symmetrical ring. Tryptophan is bound to TRAP by mostly non-polar residues<ref>PMID:16698553</ref>.
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TRAP is composed of 11 identical subunits arranged in a <scene name='59/595823/Cv/4'>symmetrical ring</scene>. The <scene name='59/595823/Cv/3'>active site of TRAP</scene><ref>PMID:16698553</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>

Current revision

Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code 2exs).

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3D Structures of tryptophan RNA-binding attenuation protein

Updated on 21-December-2020

References

  1. ↑ Li PT, Gollnick P. Characterization of a trp RNA-binding attenuation protein (TRAP) mutant with tryptophan independent RNA binding activity. J Mol Biol. 2004 Jan 16;335(3):707-22. PMID:14687568 doi:http://dx.doi.org/10.1016/S0022283603013846
  2. ↑ Heddle JG, Yokoyama T, Yamashita I, Park SY, Tame JR. Rounding up: Engineering 12-membered rings from the cyclic 11-mer TRAP. Structure. 2006 May;14(5):925-33. PMID:16698553 doi:http://dx.doi.org/10.1016/j.str.2006.03.013

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Michal Harel, Alexander Berchansky

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