1pzw

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[[Image:1pzw.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone==
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|PDB= 1pzw |SIZE=350|CAPTION= <scene name='initialview01'>1pzw</scene>, resolution 2.00&Aring;
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<StructureSection load='1pzw' size='340' side='right'caption='[[1pzw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZW FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE= grauzone ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [https://pdbe.org/1pzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [https://www.ebi.ac.uk/pdbsum/1pzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzw ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [http://www.ebi.ac.uk/pdbsum/1pzw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/GRAU_DROME GRAU_DROME] Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.<ref>PMID:10683177</ref> <ref>PMID:10924478</ref>
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== Evolutionary Conservation ==
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'''Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pzw_consurf.spt"</scriptWhenChecked>
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About one-third of the more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif, the zinc finger-associated domain (ZAD). Genes that encode ZAD proteins are specific for and expanded in the genomes of insects. Only three ZAD-encoding gene functions are established, and the role of ZAD is unknown. Here we present the crystal structure of the ZAD of Grauzone (ZAD(Grau)), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit Cortex. ZAD forms an atypical treble-clef-like zinc-coordinating fold. Head-to-tail arrangement of two ZAD(Grau) molecules in the crystals suggests dimer formation, an observation supported by crosslinking and dynamic light scattering. The results indicate that ZAD provides a novel protein-protein interaction module that characterizes a large family of insect transcription factors.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1PZW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pzw ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module., Jauch R, Bourenkov GP, Chung HR, Urlaub H, Reidt U, Jackle H, Wahl MC, Structure. 2003 Nov;11(11):1393-402. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14604529 14604529]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bourenkov, G P.]]
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[[Category: Bourenkov GP]]
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[[Category: Chung, H R.]]
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[[Category: Chung H-R]]
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[[Category: Jaeckle, H.]]
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[[Category: Jaeckle H]]
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[[Category: Jauch, R.]]
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[[Category: Jauch R]]
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[[Category: Reidt, U.]]
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[[Category: Reidt U]]
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[[Category: Urlaub, H.]]
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[[Category: Urlaub H]]
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[[Category: Wahl, M C.]]
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[[Category: Wahl MC]]
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[[Category: dimerization]]
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[[Category: transcription regulation]]
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[[Category: treble-clef zinc finger]]
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[[Category: x-ray crystallography]]
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[[Category: zad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:06:53 2008''
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Current revision

Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone

PDB ID 1pzw

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