Ubiquitin protein ligase

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<StructureSection load='' size='350' side='right' caption='Human UPL HOIP (magenta) complex with ubiquitin (green), imidazole and Zn+2 ion (grey) [[4ljo]]' scene='53/537519/Cv/1' >
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<StructureSection load='4ljo' size='340' side='right' caption='Human UPL catalytic domain trimer (grey, green, pink) complex with ubiquitin conjugating enzyme E2 (yellow) [[1c4z]]' scene='' >
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== Function ==
== Function ==
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'''Ubiquitin-protein ligase''' (UPL) ('''E3''') in combination with ubiquitin-conjugating enzyme (E2) causes the attachment of ubiquitin to lysine in a target protein<ref>PMID:16250895</ref>. '''UPL XIAP''' or '''X-linked Inhibitor of Apoptosis Protein''' stops apoptosis induced by viral infection or by overproduction of caspases. UPL XIAP binds caspase-3, -7 and -9<ref>PMID:17549347</ref>.
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'''Ubiquitin-protein ligase''' (UPL) ('''E3''') or '''E3 ubiquitin-protein ligase''' in combination with ubiquitin-conjugating enzyme (E2) causes the attachment of ubiquitin to lysine in a target protein<ref>PMID:16250895</ref>.
 +
*'''UPL XIAP''' or '''X-linked Inhibitor of Apoptosis Protein''' stops apoptosis induced by viral infection or by overproduction of caspases. UPL XIAP binds caspase-3, -7 and -9<ref>PMID:17549347</ref>. UPL XIAP is inhibited by Smac – a death signaling protein.
 +
*'''RING-type E3 ubiquitin transferase''' are E3s which do not have Zn+2 coordination<ref>PMID:23747565</ref>.
 +
*'''HOIL-1''' or '''RanBP-type and C3HC4-type zinc finger-containing protein 1''' is an atypical E3 ligase which forms ester bonds between ubiquitin and Ser/Thr residues in proteins<ref>PMID:33932090</ref>.
 +
*'''NEDD4-like Ubiquitin protein ligase WWP''' see [[WWP2]].
 +
Examples of E3 ubiquitin-protein ligases include [[Parkin]]
== Disease ==
== Disease ==
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XIAP mutations cause X-linked lymphoproliferative syndrome type 2<ref>PMID:24942515</ref>. Parkin UPL has a direct causal role in neurodegenerative disorders<ref>PMID:16908979</ref>.
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XIAP mutations cause X-linked lymphoproliferative syndrome type 2<ref>PMID:24942515</ref>. Parkin UPL has a direct causal role in neurodegenerative disorders<ref>PMID:16908979</ref>. Cereblon nonsense mutation causes autosomal recessive nonsyndromic mental retardation<ref>PMID:23983124</ref>.
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== Relevance ==
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Overexpression of UPL XIAP functions as tumor marker. UPL '''cereblon''' is inhibited by thalidomide<ref>PMID:24292623</ref> and [[Lenalidomide]].
== Structural highlights ==
== Structural highlights ==
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* '''TKB''' – Tyrosine Kinase Binding domain;<br />
* '''TKB''' – Tyrosine Kinase Binding domain;<br />
* '''C2''' – an 8 β strand domain which coordinates targeting proteins toward cell membrane;<br />
* '''C2''' – an 8 β strand domain which coordinates targeting proteins toward cell membrane;<br />
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* '''Cereblon''' is a target for thalidomide;<br />
* '''HECT''' – Homologous to the E6-AP C-terminus;<br />
* '''HECT''' – Homologous to the E6-AP C-terminus;<br />
* '''RING''' – Really Intersting New Gene involved in binding to E2;<br />
* '''RING''' – Really Intersting New Gene involved in binding to E2;<br />
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* '''UBR''' – a ca. 70 amino acid long zinc finger-like domain;<br />
* '''UBR''' – a ca. 70 amino acid long zinc finger-like domain;<br />
* '''CUE''' – a ubiquitin-binding domain.<br />
* '''CUE''' – a ubiquitin-binding domain.<br />
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'''UPL XIAP''' consists of 3 BIR (baculoviral IAP repeat) domains, followed by UBA (ubiquitin-binding) domain and RING (C-terminal RING finger) domain. BIR2 inhibits caspase-3 and -7. BIR3 inhibits caspase-9. Overexpression of UPL XIAP functions as tumor marker. UPL XIAP is inhibited by Smac – a death signaling protein.
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'''UPL XIAP''' consists of 3 BIR (baculoviral IAP repeat) domains, followed by UBA (ubiquitin-binding) domain and RING (C-terminal RING finger) domain. BIR2 inhibits caspase-3 and -7. BIR3 inhibits caspase-9.
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 +
UPL contains an thioester-forming cysteine which catalyzes the transfer of ubiquitin from E2 to a substrate lysine. The surface interacting residues of UPL and the acceptor ubiquitin are shown here<ref>PMID:24141947</ref>.
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*<scene name='53/537519/Cv/8'>Ubiquitin/protein ligase interface shown in space-filled representation</scene>.
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*<scene name='53/537519/Cv/10'>Ubiquitin/protein ligase interface interactions</scene>.
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*<scene name='53/537519/Cv/9'>1st Zn coordination site</scene>.
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*<scene name='53/537519/Cv/11'>2nd Zn coordination site</scene>.
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*<scene name='53/537519/Cv/12'>3rd Zn coordination site</scene>.
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*<scene name='53/537519/Cv/13'>4th Zn coordination site</scene>.
For some details see<br />
For some details see<br />
*[[TIR1 ubiquitin ligase]]<br />
*[[TIR1 ubiquitin ligase]]<br />
*[[Herbicide 2,4-D bound to TIR1 Ubiquitin Ligase]].
*[[Herbicide 2,4-D bound to TIR1 Ubiquitin Ligase]].
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</StructureSection>
 
== 3D Structures of ubiquitin protein ligase==
== 3D Structures of ubiquitin protein ligase==
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[[Ubiquitin protein ligase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*'''Ubiquitin protein ligase AMFR'''
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</StructureSection>
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**[[4g3o]] – hUPL CUE domain<br />
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**[[2lvn]] – hUPL CUE domain - NMR<br />
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**[[2lxh]] – hUPL RING domain - NMR<br />
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**[[2lvo]], [[2lvp]], [[2lvq]] – hUPL CUE domain + ubiquitin - NMR<br />
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**[[2lxp]] – hUPL RING+G2BR domains + E2 G2 - NMR<br />
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**[[4lad]] – hUPL RING domain (mutant) + E2 G2 <br />
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+
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*'''Ubiquitin protein ligase Arkadia'''
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**[[2kiz]] – hUPL RING-H2 finger domain - NMR<br />
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*'''Ubiquitin protein ligase CHFR'''
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+
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**[[2xoc]], [[2xoy]], [[2xoz]] – hUPL C terminal + nucleotide<br />
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**[[2xp0]] – hUPL C terminal <br />
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*'''Ubiquitin protein ligase Cbl'''
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**[[2y1m]] – hUPL - human<br />
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**[[1d5f]] – hUPL catalytic domain <br />
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**[[2dk3]] – hUPL catalytic domain - NMR<br />
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**[[1yiu]] – hUPL WW3 domain - NMR<br />
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**[[2k4d]] – hUPL RING domain<br />
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-
**[[2oo9]], [[2ooa]], [[2oob]] – hUPL UBA domain <br />
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**[[2do6]], [[2ekk]], [[2jnh]], [[2juj]] – hUPL UBA domain - NMR<br />
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-
**[[3vgo]] – hUPL N terminal <br />
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**[[2kr1]] – hUPL N terminal - NMR <br />
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**[[2ldr]] – hUPL helix-ring domain - NMR <br />
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**[[2d9s]] – mUPL UBA domain – mouse - NMR<br />
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*Ubiquitin protein ligase Cbl complex
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**[[1yvh]] – hUPL TKB domain + APS adaptor protein<br />
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**[[3bum]], [[3bun]], [[3buo]], [[3buw]], [[3bux]], [[3ob1]], [[3ob2]], [[3rlf]], [[3pfv]], [[2k4d]], [[4gpl]] – hUPL TKB domain + peptide <br />
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**[[2y1n]] – hUPL residues 47-435 + ZAP peptide <br />
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**[[4a4b]], [[4a4c]] – hUPL TKB domain (mutant) + ZAP peptide + ubiquitin conjugating enzyme E2 <br />
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**[[1c4z]] – hUPL catalytic domain + ubiquitin conjugating enzyme E2 <br />
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**[[4a49]] – hUPL residues 354-435 + ubiquitin conjugating enzyme E2 <br />
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*'''Ubiquitin protein ligase CNOT4'''
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**[[2cpi]] – mUPL RNA recognition motif - NMR <br />
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*'''Ubiquitin protein ligase DOA10'''
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**[[2m6m]] – hUPL RING domain - NMR<br />
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*'''Ubiquitin protein ligase DTX3L'''
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**[[3pg6]] – hUPL C terminal <br />
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*'''Ubiquitin protein ligase E3'''
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**[[2y1m]] – hUPL - human<br />
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**[[1d5f]] – hUPL catalytic domain <br />
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**[[2dk3]] – hUPL catalytic domain - NMR<br />
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**[[1yiu]] – hUPL WW3 domain - NMR<br />
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**[[2oo9]], [[2ooa]], [[2oob]] – hUPL UBA domain <br />
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**[[2do6]], [[2ekk]], [[2jnh]], [[2juj]] – hUPL UBA domain - NMR<br />
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**[[3vgo]] – hUPL N terminal <br />
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**[[2kr1]] – hUPL N terminal - NMR <br />
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**[[2ldr]] – hUPL helix-RING domain - NMR <br />
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**[[2d9s]] – mUPL UBA domain – mouse - NMR<br />
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*Ubiquitin protein ligase E3 complex
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**[[1yvh]] – hUPL TKB domain + APS adaptor protein<br />
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**[[3bum]], [[3bun]], [[3buo]], [[3buw]], [[3bux]], [[3ob1]], [[3ob2]], [[3rlf]], [[3pfv]] – hUPL TKB domain + peptide <br />
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**[[2y1n]] – hUPL residues 47-435 + ZAP peptide <br />
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**[[4a4b]], [[4a4c]] – hUPL TKB domain (mutant) + ZAP peptide + ubiquitin conjugating enzyme E2 <br />
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**[[1c4z]] – hUPL catalytic domain + ubiquitin conjugating enzyme E2 <br />
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**[[4a49]] – hUPL residues 354-435 + ubiquitin conjugating enzyme E2 <br />
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*'''Ubiquitin protein ligase EDD1'''
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**[[2qho]] – hUPL UBA domain + ubiquitin <br />
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*'''Ubiquitin protein ligase FANCL'''
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**[[3zqs]] – hUPL residues 109-294<br />
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**[[4ccg]] – hUPL RING domain + E2 T<br />
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*'''Ubiquitin protein ligase HAKAI'''
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**[[3vk6]] – mUPL phosphotyrosine-binding domain<br />
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*'''Ubiquitin protein ligase HECTD1'''
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**[[3dkm]] – hUPL CPH domain <br />
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**[[2lc3]] – hUPL helical bundle domain - NMR<br />
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*'''Ubiquitin protein ligase HECW'''
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**[[3l4h]] – hUPL WW2 and helical box domains <br />
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**[[2lfe]] – hUPL N terminal - NMR<br />
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+
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*'''Ubiquitin protein ligase HERC'''
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**[[4o2w]] – hUPL 1 3rd RCC1-like domain <br />
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**[[4l1m]] – hUPL 2 1st RCC1-like domain <br />
+
-
 
+
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*'''Ubiquitin protein ligase HHARI'''
+
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+
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**[[4kbl]], [[4kc9]] – hUPL<br />
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**[[2m9y]] – hUPL catalytic domain - NMR<br />
+
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+
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*'''Ubiquitin protein ligase HUWE1'''
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+
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**[[3g1n]] – hUPL catalytic domain <br />
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**[[3h1d]] – hUPL HECT domain (mutant)<br />
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*'''Ubiquitin protein ligase ITCHY'''
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**[[2jo9]] – mUPL WW3 domain + Epstein-Barr virus peptide - NMR <br />
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**[[2joc]], [[2ysf]], [[2kyk]] – mUPL WW domain - NMR <br />
+
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**[[3tug]] – hUPL HECT domain <br />
+
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**[[2nq3]] – hUPL C2 domain <br />
+
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**[[2dmv]] – mUPL WW2 domain - NMR <br />
+
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+
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*'''Ubiquitin protein ligase LNX'''
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**[[3vqf]] – mUPL 2rd PDZ domain <br />
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**[[3b76]] – hUPL 3rd PDZ domain <br />
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**[[3vqg]] – mUPL 2rd PDZ domain + peptide<br />
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*'''Ubiquitin protein ligase MDM2''' see [[MDM2]]
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*'''Ubiquitin protein ligase MYCBP2'''
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**[[3gbw]] – mUPL 1st PHR domain <br />
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**[[3hwj]] – mUPL 2nd PHR domain <br />
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*'''Ubiquitin protein ligase MYLIP'''
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**[[2yhn]] – hUPL RING domain <br />
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**[[2yho]] – hUPL RING domain + ubiquitin-conjugating enzyme<br />
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*'''Ubiquitin protein ligase NEDD4'''
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**[[1wr3]], [[1wr4]], [[1wr7]] – mUPL WW domain - NMR <br />
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**[[2oni]] – hUPL catalytic domain <br />
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**[[3b7y]] – hUPL C2 domain <br />
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**[[2xbf]] – hUPL HECT domain <br />
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**[[4be8]] – hUPL HECT domain (mutant) <br />
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*Ubiquitin protein ligase NEDD4 complex
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**[[1i5h]] – rUPL WW3 domain + amiloride-sensitive Na channel β subunit – rat <br />
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**[[2ltx]], [[2lty]] – hUPL WW2 domain + peptide - NMR <br />
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**[[2ez5]] – UPL WW3 domain + COMM LPSY peptide – ''Drosophila melanogaster'' - NMR <br />
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**[[2kpz]], [[2kq0]], [[2laj]], [[2ltz]], [[2m3o]] – hUPL WW3 domain + peptide - NMR <br />
+
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**[[4n7h]] – hUPL WW3 domain + arrestin peptide <br />
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**[[2lb2]] – hUPL 2nd domain + peptide - NMR <br />
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**[[3m7f]] – hUPL C2 domain + growth factor receptor bound protein<br />
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**[[3jvz]], [[3jw0]] – hUPL HECT domain + ubiquitin + ubiquitin-conjugating enzyme<br />
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**[[2xbb]] – hUPL HECT domain + ubiquitin <br />
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**[[4bbn]] – hUPL HECT domain (mutant) + polyubiquitin <br />
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*'''Ubiquitin protein ligase Praja'''
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**[[2l0b]] – hUPL RING-type zinc finger domain - NMR<br />
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*'''Ubiquitin protein ligase PARKIN'''
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**[[4k95]] – rUPL <br />
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**[[2jmo]] – hUPL IBR domain - NMR <br />
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**[[2zeq]] – hUPL ubiquitin-like domain <br />
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**[[4bm9]], [[4i1h]] – hUPL catalytic domain <br />
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**[[4i1f]] – hUPL catalytic domain (mutant)<br />
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**[[3b1l]] – mUPL ubiquitin-like domain <br />
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**[[4k7d]] – rUPL C terminal domain <br />
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**[[2knb]] – rUPL + endophilin - NMR <br />
+
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*'''Ubiquitin protein ligase RAD18'''
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**[[2y43]] – hUPL RING domain <br />
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*'''Ubiquitin protein ligase RBBP6'''
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**[[3ztg]] – hUPL RING domain - NMR <br />
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*'''Ubiquitin protein ligase RBX'''
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**[[2lgv]] – hUPL residues 5-108 (mutant) - NMR <br />
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**[[3rtr]], [[4f52]] – hUPL residues 5-108 + cullin-1 <br />
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**[[4a0k]], [[4a0c]] – hUPL residues 12-108 + cullin-4B + cullin-associated NEDD8-dissociated protein<br />
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**[[4a0l]] – hUPL residues 12-108 + cullin-4B + DNA damage-binding protein + DNA<br />
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*'''Ubiquitin protein ligase RING2'''
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**[[2ckl]] – mUPL RING domain + polycomb group ring finger protein 4 <br />
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**[[2h0d]] – mUPL RING domain + B lymphoma MO-MLV insertion region <br />
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**[[3h8h]] – hUPL C terminal <br />
+
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**[[3gs2]] – hUPL C terminal + chromobox protein homolog<br />
+
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**[[3ixs]] – hUPL C terminal (mutant) + RING1 and YY1-binding protein<br />
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**[[3rpg]] – hUPL + polycomb complex protein BMI-1 + E2 D3 <br />
+
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*'''Ubiquitin protein ligase RNF'''
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**[[4ppe]] – hUPL RING domain <br />
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**[[4ap4]] – hUPL 4 residues 131-195 + E2 + ubiquitin<br />
+
-
**[[2pie]] – hUPL 8 FHA domain <br />
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**[[2csw]] – hUPL 8 FHA domain - NMR <br />
+
-
**[[4ayc]], [[4gb0]] – hUPL 8 RING domain <br />
+
-
**[[4orh]] – hUPL 8 residues 345-485 + E2 <br />
+
-
**[[4juy]], [[4oyj]], [[4p09]] – hUPL 31 PUB domain <br />
+
-
**[[4ljq]] – hUPL 31 catalytic domain <br />
+
-
**[[4ljo]] – hUPL 31 catalytic domain + ubiquitin<br />
+
-
**[[4ljp]] – hUPL 31 catalytic domain (mutant) + ubiquitin<br />
+
-
**[[4owf]] – hUPL 31 catalytic domain + nf-κ-B modulator<br />
+
-
**[[4oyk]], [[4p0b]] – hUPL 31 PUB domain + otulin<br />
+
-
**[[4p0a]] – hUPL 31 PUB domain + p97 peptide<br />
+
-
**[[4kng]] – hUPL 43 PA domain + LGR5 + RSPO1<br />
+
-
**[[2ma6]] – hUPL 123 RING domain - NMR<br />
+
-
**[[3icu]] – hUPL 128 protease-associated domain <br />
+
-
**[[3v3l]] – hUPL 146 WWE domain <br />
+
-
**[[2rsf]] – mUPL 146 WWE domain + ATP<br />
+
-
**[[3l11]], [[4gb0]] – hUPL 168 RING domain <br />
+
-
 
+
-
*'''Ubiquitin protein ligase RSP'''
+
-
 
+
-
**[[4lcd]] – hUPL 3 HECT + WW3 domains (mutant) + SNA3 peptide + ubiquitin <br />
+
-
**[[3olm]] – hUPL 5 HECT + WW3 domains + ubiquitin <br />
+
-
 
+
-
*'''Ubiquitin protein ligase SHPRH'''
+
-
 
+
-
**[[2m85]] – hUPL PHD domain - NMR<br />
+
-
 
+
-
*'''Ubiquitin protein ligase SIAH1'''
+
-
 
+
-
**[[4c9z]], [[4ca1]] – hUPL zinc finger+substrate binding domains <br />
+
-
**[[2a25]] – hUPL substrate binding domain + calcyclin-binding protein peptide <br />
+
-
**[[4i7b]], [[4i7d]] – hUPL C terminal + phyllopod peptide <br />
+
-
**[[4i7c]] – hUPL C terminal (mutant) + phyllopod peptide <br />
+
-
**[[2an6]] – mUPL residues 92-282 + phyllopod peptide <br />
+
-
 
+
-
*'''Ubiquitin protein ligase SMURF'''
+
-
 
+
-
**[[2jqz]] – hUPL - NMR <br />
+
-
**[[2kxq]] – hUPL WW2 and WW3 + peptide<br />
+
-
**[[2laz]], [[2lb0]], [[2lb1]], [[2ltx]] – hUPL WW + peptide - NMR<br />
+
-
**[[3pyc]] – hUPL C2 domain <br />
+
-
 
+
-
*'''Ubiquitin protein ligase SOPA'''
+
-
 
+
-
**[[3sy2]] – SeUPL residues 165-782 + ubiquitin + ubiquitin-conjugating enzyme – ''Salmonella enterica''<br />
+
-
 
+
-
*'''Ubiquitin protein ligase SSPH1'''
+
-
 
+
-
**[[4nkh]] –SeUPL 21 LRR domain <br />
+
-
**[[4nkg]] –SeUPL 21 LRR domain + Ser/Thr protein kinase N1 peptide<br />
+
-
 
+
-
*'''Ubiquitin protein ligase TIR1'''
+
-
 
+
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**[[2p1q]] – AtUPL + auxin response protein + SKP1-like protein – ''Arabidopsis thaliana''<br />
+
-
**[[2p1q]] – AtUPL + auxin response protein + SKP1-like protein + herbicide<br />
+
-
 
+
-
*'''Ubiquitin protein ligase TRIM'''
+
-
 
+
-
**[[3zo0]] – mUPL 21 residues 291-470 + IG γ-2A<br />
+
-
**[[4b8e]] – mUPL 25 PRY-SPRY domain <br />
+
-
**[[3u5m]] – hUPL 33 PHD+Bromo domains <br />
+
-
**[[3u5n]], [[3u5o]], [[3u5p]] – hUPL 33 PHD+Bromo domain + H3-histone peptide <br />
+
-
**[[3ddt]] – hUPL 37 B2-box <br />
+
-
**[[4m3l]] – hUPL 63 coiled-coil domain <br />
+
-
**[[4nqj]] – hUPL 69 coiled-coil domain <br />
+
-
 
+
-
*'''Ubiquitin protein ligase UBR'''
+
-
 
+
-
**[[3ny1]], [[3ny2]] – hUPL UBR-box <br />
+
-
**[[3pt3]] – hUPL C terminal <br />
+
-
**[[3ny3]] – hUPL UBR-box + N-degron<br />
+
-
**[[3nih]], [[3nii]], [[3nij]], [[3nik]], [[3nil]], [[3nim]], [[3nin]] – yUPL UBR-box + peptide - yeast<br />
+
-
**[[3nis]], [[3nit]] – yUPL UBR-box <br />
+
-
**[[3ntw]] – rUPL MLLE domain + peptide <br />
+
-
 
+
-
*'''Ubiquitin protein ligase UHRF (Np95)'''
+
-
 
+
-
**[[3sox]], [[3zvz]] – hUPL 1 PHD finger <br />
+
-
**[[2lgl]] – hUPL 1 PHD finger - NMR <br />
+
-
**[[2e6s]] – hUPL 2 PHD finger - NMR <br />
+
-
**[[3zvy]] – hUPL 1 PHD finger + histone H3 peptide<br />
+
-
**[[3bi7]], [[2pb7]], [[2zkg]], [[3dwh]] – hUPL 1 SRA domain <br />
+
-
**[[3oln]] – hUPL 2 SRA domain <br />
+
-
**[[3db4]] – hUPL 1 TUDOR domain <br />
+
-
**[[3fl2]] – hUPL 1 RING domain <br />
+
-
 
+
-
*Ubiquitin protein ligase UHRF complex
+
-
 
+
-
**[[3clz]], [[2zkd]], [[2zke]], [[2zkf]] – hUPL 1 SRA domain + DNA<br />
+
-
**[[4pw5]], [[4pw6]], [[4pw7]] – hUPL 2 SRA domain + DNA<br />
+
-
**[[2zo0]], [[2zo1]], [[2zo2]], [[3f8i]], [[3f8j]], [[3fde]] – mUPL 1 SRA domain + DNA<br />
+
-
**[[3sou]], [[3sow]], [[3shb]], [[2lgg]], [[3t6r]], [[3ask]], [[3asl]], [[4gy5]] – hUPL 1 PHD finger + histone H3 peptide<br />
+
-
**[[2lgk]] – hUPL 1 PHD finger + histone H3 peptide - NMR<br />
+
-
**[[3db3]] – hUPL 1 TUDOR domain + histone H3 peptide<br />
+
-
**[[2l3r]] – hUPL 1 TUDOR domain + histone H3 peptide - NMR<br />
+
-
 
+
-
*'''Ubiquitin protein ligase WWP1'''
+
-
 
+
-
**[[2jqz]] – hUPL WW4 domain - NMR <br />
+
-
 
+
-
*'''Ubiquitin protein ligase XIAP'''
+
-
 
+
-
*Ubiquitin protein ligase XIAP BIR-1 domain
+
-
 
+
-
**[[2poi]], [[2qra]] – hXIAP – human <BR />
+
-
**[[2pop]] – hXIAP + TAB1 <BR />
+
-
 
+
-
*Ubiquitin protein ligase XIAP BIR-2 domain
+
-
 
+
-
**[[1c9q]] – hXIAP (mutant) – NMR <BR />
+
-
**[[4j3y]] – hXIAP (mutant) <BR />
+
-
**[[4j44]], [[4j45]], [[4j46]], [[4j47]], [[4j48]] - hXIAP (mutant) + peptide<BR />
+
-
**[[1i3o]] – hXIAP (mutant) + caspase-3 <BR />
+
-
**[[1i4o]], [[1kmc]], [[1i51]] – hXIAP + caspase-7 <BR />
+
-
**[[4kmp]] - hXIAP + inhibitor<BR />
+
-
**[[4kju]], [[4kjv]] - hXIAP (mutant) + inhibitor<BR />
+
-
**[[3uw5]] – hXIAP residues 63-179 (mutant) + GDC0152 + inhibitor<br /> <BR />
+
-
 
+
-
*Ubiquitin protein ligase XIAP BIR-3 domain
+
-
 
+
-
**[[1f9x]] – hXIAP – NMR <BR />
+
-
**[[1g3f]] – hXIAP + Smac peptide – NMR <BR />
+
-
**[[2opz]] – hXIAP + Smac peptide <BR />
+
-
**[[2opy]], [[2vsl]], [[3clx]], [[3cm2]], [[3cm7]], [[2jk7]], [[3eyl]], [[3g76]], [[4ec4]] – hXIAP + Smac mimic <BR />
+
-
**[[1g73]] – hXIAP + Smac <BR />
+
-
**[[1nw9]] – hXIAP + caspase-9 <BR />
+
-
**[[1tfq]], [[1tft]] – hXIAP + inhibitor - NMR <BR />
+
-
**[[3hl5]], [[4hy0]] – hXIAP + inhibitor <BR />
+
-
**[[3uw4]] – hXIAP (mutant) + peptide + inhibitor <BR />
+
-
 
+
-
*Ubiquitin protein ligase XIAP UBA domain
+
-
 
+
-
**[[2kna]] – hXIAP – NMR <BR />
+
-
 
+
-
*Ubiquitin protein ligase XIAP RING domain
+
-
 
+
-
**[[4ic2]] – hXIAP <BR />
+
-
**[[2ecg]] – hXIAP – NMR <BR />
+
-
**[[4ic3]] – hXIAP (mutant) <BR />
+
-
 
+
-
*'''Ubiquitin protein ligase ZNRF3'''
+
-
 
+
-
**[[4c84]], [[4c85]], [[4c86]], [[4c8a]], [[4c8c]], [[4c8f]] – zUPL ectodomain – zebra fish <br />
+
-
**[[4c8p]] – zUPL ectodomain (mutant) <br />
+
-
**[[4c8t]], [[4c8u]] – fUPL ectodomain – frog <br />
+
-
**[[4cdj]] – mUPL ectodomain <br />
+
-
**[[4c99]], [[4c9a]], [[4c9e]], [[4c9r]], [[4c9u]], [[4cdk]] – mUPL ectodomain + R-spondin <br />
+
-
 
+
-
*'''Ubiquitin protein ligase ZFP91'''
+
-
 
+
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**[[2m9a]] – hUPL residues 370-456 - NMR<br />
+
-
}}
 
==References==
==References==
<references />
<references />
-
[[Category:Topic Page]]
+
[[Category:Topic Page]] + phosphoubiquitin

Current revision

Human UPL HOIP (magenta) complex with ubiquitin (green), imidazole and Zn+2 ion (grey) 4ljo

Drag the structure with the mouse to rotate

References

  1. ↑ Ardley HC, Robinson PA. E3 ubiquitin ligases. Essays Biochem. 2005;41:15-30. PMID:16250895 doi:http://dx.doi.org/10.1042/EB0410015
  2. ↑ Sakemi R, Yano H, Ogasawara S, Akiba J, Nakashima O, Fukahori S, Sata M, Kojiro M. X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues. Oncol Rep. 2007 Jul;18(1):65-70. PMID:17549347
  3. ↑ Metzger MB, Pruneda JN, Klevit RE, Weissman AM. RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys Acta. 2014 Jan;1843(1):47-60. PMID:23747565 doi:10.1016/j.bbamcr.2013.05.026
  4. ↑ Petrova T, Zhang J, Nanda SK, Figueras-Vadillo C, Cohen P. HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages. FEBS J. 2021 Oct;288(20):5909-5924. PMID:33932090 doi:10.1111/febs.15896
  5. ↑ Aguilar C, Lenoir C, Lambert N, Begue B, Brousse N, Canioni D, Berrebi D, Roy M, Gerart S, Chapel H, Schwerd T, Siproudhis L, Schappi M, Al-Ahmari A, Mori M, Yamaide A, Galicier L, Neven B, Routes J, Uhlig HH, Koletzko S, Patel S, Kanegane H, Picard C, Fischer A, Bensussan NC, Ruemmele F, Hugot JP, Latour S. Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers. J Allergy Clin Immunol. 2014 Nov;134(5):1131-41.e9. doi:, 10.1016/j.jaci.2014.04.031. Epub 2014 Jun 15. PMID:24942515 doi:http://dx.doi.org/10.1016/j.jaci.2014.04.031
  6. ↑ Ardley HC, Robinson PA. The role of ubiquitin-protein ligases in neurodegenerative disease. Neurodegener Dis. 2004;1(2-3):71-87. PMID:16908979 doi:http://dx.doi.org/10.1159/000080048
  7. ↑ Xu G, Jiang X, Jaffrey SR. A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition. J Biol Chem. 2013 Oct 11;288(41):29573-85. doi: 10.1074/jbc.M113.472092. Epub, 2013 Aug 27. PMID:23983124 doi:http://dx.doi.org/10.1074/jbc.M113.472092
  8. ↑ Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG Jr. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science. 2014 Jan 17;343(6168):305-9. doi: 10.1126/science.1244917. Epub 2013 Nov, 29. PMID:24292623 doi:http://dx.doi.org/10.1126/science.1244917
  9. ↑ Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K. Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature. 2013 Oct 20. doi: 10.1038/nature12638. PMID:24141947 doi:http://dx.doi.org/10.1038/nature12638
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