1q01

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:14, 30 October 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1q01.gif|left|200px]]
 
-
{{Structure
+
==Lebetin peptides, a new class of potent aggregation inhibitors==
-
|PDB= 1q01 |SIZE=350|CAPTION= <scene name='initialview01'>1q01</scene>
+
<StructureSection load='1q01' size='340' side='right'caption='[[1q01]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1q01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrovipera_lebetinus Macrovipera lebetinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q01 FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 24 models</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q01 OCA], [https://pdbe.org/1q01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q01 RCSB], [https://www.ebi.ac.uk/pdbsum/1q01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q01 ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q01 OCA], [http://www.ebi.ac.uk/pdbsum/1q01 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q01 RCSB]</span>
+
[https://www.uniprot.org/uniprot/LEB_MACLB LEB_MACLB] Lebetins inhibit platelet aggregation induced by thrombin, collagen and PAF-acether. Human platelet aggregation induced by thrombin is inhibited by synthetic lebetin-1-alpha, lebetin-1-beta, lebetin-1-gamma, lebetin-2-alpha and lebetin-2-beta with IC(50) values of 140, 32, 5, 2.5 and 2.8 nM, respectively. Lebetins also inhibit fibrinogen-induced aggregation of alpha-chymotrypsin-treated platelets as well as in vivo collagen-induced thrombocytopenia in rats. Lebetins are not toxic upon intravenous injection into mice and rats.<ref>PMID:11910186</ref> <ref>PMID:8769304</ref> <ref>PMID:9839678</ref>
-
}}
+
== References ==
-
 
+
<references/>
-
'''Lebetin peptides, a new class of potent aggregation inhibitors'''
+
__TOC__
-
 
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==About this Structure==
+
[[Category: Macrovipera lebetinus]]
-
1Q01 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Macrovipera_lebetina Macrovipera lebetina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q01 OCA].
+
[[Category: Darbon H]]
-
[[Category: Macrovipera lebetina]]
+
[[Category: El Ayeb M]]
-
[[Category: Single protein]]
+
[[Category: Ganzalez MJ]]
-
[[Category: Ayeb, M El.]]
+
[[Category: Giralt E]]
-
[[Category: Darbon, H.]]
+
[[Category: Mabrouk K]]
-
[[Category: Ganzalez, M J.]]
+
[[Category: Marrakchi N]]
-
[[Category: Giralt, E.]]
+
[[Category: Mosbah A]]
-
[[Category: Mabrouk, K.]]
+
[[Category: Rochat H]]
-
[[Category: Marrakchi, N.]]
+
[[Category: Sabatier JM]]
-
[[Category: Mosbah, A.]]
+
[[Category: Van Rietschoten J]]
-
[[Category: Rietschoten, J Van.]]
+
-
[[Category: Rochat, H.]]
+
-
[[Category: Sabatier, J M.]]
+
-
[[Category: beta-bulged hairpain]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:06:58 2008''
+

Current revision

Lebetin peptides, a new class of potent aggregation inhibitors

PDB ID 1q01

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q01"
Personal tools