1q09

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:11, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1q09.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator (space group I4122)==
-
|PDB= 1q09 |SIZE=350|CAPTION= <scene name='initialview01'>1q09</scene>, resolution 2.50&Aring;
+
<StructureSection load='1q09' size='340' side='right'caption='[[1q09]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[1q09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q09 FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
|GENE= ZNTR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q09 OCA], [https://pdbe.org/1q09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q09 RCSB], [https://www.ebi.ac.uk/pdbsum/1q09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q09 ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1q08|1Q08]], [[1q0a|1Q0A]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q09 OCA], [http://www.ebi.ac.uk/pdbsum/1q09 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q09 RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/ZNTR_ECOLI ZNTR_ECOLI] Zinc-responsive transcriptional regulator of zntA.
-
 
+
== Evolutionary Conservation ==
-
'''Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator (space group I4122)'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==Overview==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q0/1q09_consurf.spt"</scriptWhenChecked>
-
The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR reveals a zeptomolar (10(-21) molar) sensitivity to free Cu+, which is far less than one atom per cell. Atomic details of this extraordinary sensitivity and selectivity for +1transition-metal ions are revealed by comparing the crystal structures of CueR and a Zn2+-sensing homolog, ZntR. An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding. This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1Q09 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q09 OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q09 ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR., Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A, Science. 2003 Sep 5;301(5638):1383-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12958362 12958362]
+
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Changela, A.]]
+
[[Category: Changela A]]
-
[[Category: Chen, K.]]
+
[[Category: Chen K]]
-
[[Category: Halloran, T V.O.]]
+
[[Category: Holschen J]]
-
[[Category: Holschen, J.]]
+
[[Category: Mondragon A]]
-
[[Category: Mondragon, A.]]
+
[[Category: O'Halloran TV]]
-
[[Category: Outten, C E.]]
+
[[Category: Outten CE]]
-
[[Category: Xue, Y.]]
+
[[Category: Xue Y]]
-
[[Category: merr family transcriptional regulator]]
+
-
[[Category: zn(ii)-responsive regulator of znta]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:07:02 2008''
+

Current revision

Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator (space group I4122)

PDB ID 1q09

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q09"
Personal tools