5h47

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 5h47 is ON HOLD until Paper Publication Authors: Kato, R., Nishikawa, Y., Makyio, H. Description: Crystal structure of AOL complexed with 2-MeSe-Fu...)
Current revision (09:14, 20 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5h47 is ON HOLD until Paper Publication
+
==Crystal structure of AOL complexed with 2-MeSe-Fuc==
-
 
+
<StructureSection load='5h47' size='340' side='right'caption='[[5h47]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
Authors: Kato, R., Nishikawa, Y., Makyio, H.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5h47]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_oryzae_RIB40 Aspergillus oryzae RIB40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H47 FirstGlance]. <br>
-
Description: Crystal structure of AOL complexed with 2-MeSe-Fuc
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FSW:(2S,3S,4R,5S,6R)-6-METHOXY-2-METHYL-5-METHYLSELANYL-OXANE-3,4-DIOL'>FSW</scene></td></tr>
-
[[Category: Makyio, H]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h47 OCA], [https://pdbe.org/5h47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h47 RCSB], [https://www.ebi.ac.uk/pdbsum/5h47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h47 ProSAT]</span></td></tr>
-
[[Category: Nishikawa, Y]]
+
</table>
-
[[Category: Kato, R]]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/LECF_ASPOR LECF_ASPOR] Lectin that specifically binds to L-fucose and weakly reacts with mannose and N-acetyl-neuraminic acid (PubMed:12092808, PubMed:27318092, PubMed:28041800). Has strongest preference for the alpha-1,6-fucosylated chain (core fucose) on glycoproteins among alpha-1,2-, alpha-1,3-, alpha-1,4-, and alpha-1,6-fucosylated chains (PubMed:17383961, PubMed:19109923). Binds to fucose residues of IgE in mice and human, causing antigen-independent IgE-mediated mast cell activation and anaphylactoid reactions in mice and is possibly implicated in allergic response to Aspergillus oryzae in humans (PubMed:21790704). Induces secretion of pro-inflammatory cytokines IL6 and IL8 implicated in ocular diseases such as mycotic keratitis, probably through its interaction with host toll-like receptors TLR2 and TLR4, followed by up-regulation of pro-inflammatory cytokines (PubMed:28470344).<ref>PMID:12092808</ref> <ref>PMID:17383961</ref> <ref>PMID:19109923</ref> <ref>PMID:21790704</ref> <ref>PMID:27318092</ref> <ref>PMID:28041800</ref> <ref>PMID:28470344</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Aspergillus oryzae RIB40]]
 +
[[Category: Large Structures]]
 +
[[Category: Kato R]]
 +
[[Category: Makyio H]]
 +
[[Category: Nishikawa Y]]

Current revision

Crystal structure of AOL complexed with 2-MeSe-Fuc

PDB ID 5h47

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5h47"
Personal tools