1q35

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[[Image:1q35.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of Pasteurella haemolytica Apo Ferric ion-Binding Protein A==
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|PDB= 1q35 |SIZE=350|CAPTION= <scene name='initialview01'>1q35</scene>, resolution 1.20&Aring;
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<StructureSection load='1q35' size='340' side='right'caption='[[1q35]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>
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<table><tr><td colspan='2'>[[1q35]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mannheimia_haemolytica Mannheimia haemolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q35 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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|GENE= fbpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=75985 Mannheimia haemolytica])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q35 OCA], [https://pdbe.org/1q35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q35 RCSB], [https://www.ebi.ac.uk/pdbsum/1q35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q35 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q35 OCA], [http://www.ebi.ac.uk/pdbsum/1q35 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q35 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q9Z4N6_MANHA Q9Z4N6_MANHA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q35_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q35 ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Pasteurella haemolytica Apo Ferric ion-Binding Protein A'''
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==See Also==
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*[[Ferric-binding protein|Ferric-binding protein]]
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__TOC__
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==Overview==
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</StructureSection>
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Pasteurellosis caused by the Gram-negative pathogen Pasteurella haemolytica is a serious disease leading to death in cattle. To scavenge growth-limiting iron from the host, the pathogen utilizes the periplasmic ferric ion-binding protein A (PhFbpA) as a component of an ATP-binding cassette transport pathway. We report the 1.2-A structure of the iron-free (apo) form of PhFbpA, which is a member of the transferrin structural superfamily. The protein structure adopts a closed conformation, allowing us to reliably assign putative iron-coordinating residues. Based on our analysis, PhFbpA utilizes a unique constellation of binding site residues and anions to octahedrally coordinate an iron atom. A surprising finding in the structure is the presence of two formate anions on opposite sides of the iron-binding pocket. The formate ions tether the N- and C-terminal domains of the protein and stabilize the closed structure, also providing clues as to probable candidates for synergistic anions in the iron-loaded state. PhFbpA represents a new class of bacterial iron-binding proteins.
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[[Category: Large Structures]]
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==About this Structure==
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1Q35 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mannheimia_haemolytica Mannheimia haemolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q35 OCA].
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==Reference==
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Crystal structure of Pasteurella haemolytica ferric ion-binding protein A reveals a novel class of bacterial iron-binding proteins., Shouldice SR, Dougan DR, Williams PA, Skene RJ, Snell G, Scheibe D, Kirby S, Hosfield DJ, McRee DE, Schryvers AB, Tari LW, J Biol Chem. 2003 Oct 17;278(42):41093-8. Epub 2003 Jul 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12882966 12882966]
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[[Category: Mannheimia haemolytica]]
[[Category: Mannheimia haemolytica]]
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[[Category: Single protein]]
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[[Category: Dougan DR]]
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[[Category: Dougan, D R.]]
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[[Category: Kirby S]]
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[[Category: Kirby, S.]]
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[[Category: McRee DE]]
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[[Category: McRee, D E.]]
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[[Category: Scheibe D]]
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[[Category: Scheibe, D.]]
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[[Category: Schryvers AB]]
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[[Category: Schryvers, A B.]]
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[[Category: Shouldice SR]]
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[[Category: Shouldice, S R.]]
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[[Category: Skene RJ]]
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[[Category: Skene, R J.]]
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[[Category: Snell G]]
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[[Category: Snell, G.]]
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[[Category: Tari LW]]
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[[Category: Tari, L W.]]
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[[Category: Williams PA]]
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[[Category: Williams, P A.]]
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[[Category: iron binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:08:12 2008''
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Current revision

Crystal Structure of Pasteurella haemolytica Apo Ferric ion-Binding Protein A

PDB ID 1q35

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OCA

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