5h7e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of native drCPDase== | |
| + | <StructureSection load='5h7e' size='340' side='right'caption='[[5h7e]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5h7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H7E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h7e OCA], [https://pdbe.org/5h7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h7e RCSB], [https://www.ebi.ac.uk/pdbsum/5h7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h7e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/O32509_DEIRD O32509_DEIRD] Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.[HAMAP-Rule:MF_01940] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | 2',3'-Cyclic phosphodiesterase (CPDase) homologues have been found in all domains of life and are involved in diverse RNA and nucleotide metabolisms. The CPDase from Deinococcus radiodurans was crystallized and the crystals diffracted to 1.6 A resolution, which is the highest resolution currently known for a CPDase structure. Structural comparisons revealed that the enzyme is in an open conformation in the absence of substrate. Nevertheless, the active site is well formed, and the representative motifs interact with sulfate ion, which suggests a conserved catalytic mechanism. | ||
| - | + | Crystal structure of the RNA 2',3'-cyclic phosphodiesterase from Deinococcus radiodurans.,Han W, Cheng J, Zhou C, Hua Y, Zhao Y Acta Crystallogr F Struct Biol Commun. 2017 May 1;73(Pt 5):276-280. doi:, 10.1107/S2053230X17004964. Epub 2017 Apr 26. PMID:28471359<ref>PMID:28471359</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5h7e" style="background-color:#fffaf0;"></div> |
| - | [[Category: Han | + | == References == |
| - | [[Category: Hua | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Deinococcus radiodurans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Han W]] | ||
| + | [[Category: Hua Y]] | ||
| + | [[Category: Zhao Y]] | ||
Current revision
Crystal Structure of native drCPDase
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