5h7w
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5h7w is ON HOLD Authors: Chang, C., Wu, W.G. Description: Crystal structure of 5'-nucleotidase from venom of Naja atra [[Category: Unreleased Struc...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 5'-nucleotidase from venom of Naja atra== | |
| - | + | <StructureSection load='5h7w' size='340' side='right'caption='[[5h7w]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h7w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H7W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h7w OCA], [https://pdbe.org/5h7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h7w RCSB], [https://www.ebi.ac.uk/pdbsum/5h7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h7w ProSAT]</span></td></tr> |
| - | [[Category: Chang | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/V5NTD_NAJAT V5NTD_NAJAT] Hydrolyzes nucleotides into nucleosides (By similarity). Snake venom 5'-nucleotidases are widely distributed among venomous snake taxa, but there is a lack of information about their biological activities. They have been shown to inhibit platelet aggregation. This effect may be due to the liberation of inhibitory AMP or adenosine by its action on ADP released upon initiation of aggregation. Venom 5'-nucleotidases are also known to synergistically act in vivo with other toxins like ADPases, phospholipases, and disintegrins to exert a more pronounced anti-coagulant effect.[UniProtKB:P0DJJ5]<ref>PMID:20186872</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Naja atra]] | ||
| + | [[Category: Chang C]] | ||
| + | [[Category: Lin C-C]] | ||
| + | [[Category: Wu W-G]] | ||
Current revision
Crystal structure of 5'-nucleotidase from venom of Naja atra
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Categories: Large Structures | Naja atra | Chang C | Lin C-C | Wu W-G
