5j26

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'''Unreleased structure'''
 
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The entry 5j26 is ON HOLD
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==Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant==
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<StructureSection load='5j26' size='340' side='right'caption='[[5j26]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Wan, L., Canny, M., Juang, Y.C., Durocher, D., Sicheri, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5j26]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J26 FirstGlance]. <br>
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Description: Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5047&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j26 OCA], [https://pdbe.org/5j26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j26 RCSB], [https://www.ebi.ac.uk/pdbsum/5j26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j26 ProSAT]</span></td></tr>
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[[Category: Durocher, D]]
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</table>
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[[Category: Juang, Y.C]]
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== Disease ==
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[[Category: Wan, L]]
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
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[[Category: Canny, M]]
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== Function ==
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[[Category: Sicheri, F]]
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Canny M]]
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[[Category: Durocher D]]
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[[Category: Juang YC]]
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[[Category: Sicheri F]]
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[[Category: Wan L]]

Current revision

Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant

PDB ID 5j26

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