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1q5b

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[[Image:1q5b.gif|left|200px]]
 
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{{Structure
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==lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography==
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|PDB= 1q5b |SIZE=350|CAPTION= <scene name='initialview01'>1q5b</scene>
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<SX load='1q5b' size='340' side='right' viewer='molstar' caption='[[1q5b]], [[Resolution|resolution]] 30.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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<table><tr><td colspan='2'>[[1q5b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q5B FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 30&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5b OCA], [https://pdbe.org/1q5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q5b RCSB], [https://www.ebi.ac.uk/pdbsum/1q5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q5b ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1l3w|1L3W]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5b OCA], [http://www.ebi.ac.uk/pdbsum/1q5b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q5b RCSB]</span>
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== Evolutionary Conservation ==
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}}
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/1q5b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q5b ConSurf].
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<div style="clear:both"></div>
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'''lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography'''
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==See Also==
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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__TOC__
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==Overview==
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</SX>
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Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion remain controversial. We used electron tomography of plastic sections from neonatal mouse skin to visualize the organization of desmosomes in situ. The resulting three-dimensional maps reveal individual cadherin molecules forming discrete groups and interacting through their tips. Fitting of an x-ray crystal structure for C-cadherin to these maps is consistent with a flexible intermolecular interface mediated by an exchange of amino-terminal tryptophans. This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction.
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[[Category: Large Structures]]
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==About this Structure==
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1Q5B is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5B OCA].
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==Reference==
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Untangling desmosomal knots with electron tomography., He W, Cowin P, Stokes DL, Science. 2003 Oct 3;302(5642):109-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14526082 14526082]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Cowin P]]
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[[Category: Cowin, P.]]
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[[Category: He W]]
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[[Category: He, W.]]
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[[Category: Stokes DL]]
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[[Category: Stokes, D L.]]
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[[Category: adhesion]]
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[[Category: cadherin]]
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[[Category: desmosome]]
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[[Category: junction]]
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[[Category: trans interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:08:58 2008''
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Current revision

lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography

1q5b, resolution 30.00Å

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