5mhj
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5mhj is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures) |
|||
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==ICP4 DNA-binding domain, lacking intrinsically disordered region, in complex with 12mer DNA duplex from its own promoter== | |
| - | + | <StructureSection load='5mhj' size='340' side='right'caption='[[5mhj]], [[Resolution|resolution]] 2.12Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mhj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MHJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.117Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhj OCA], [https://pdbe.org/5mhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mhj RCSB], [https://www.ebi.ac.uk/pdbsum/5mhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ICP4_HHV11 ICP4_HHV11] Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription.<ref>PMID:18094162</ref> <ref>PMID:18216093</ref> <ref>PMID:1846804</ref> <ref>PMID:22496239</ref> <ref>PMID:23135715</ref> <ref>PMID:24147125</ref> <ref>PMID:8649420</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human alphaherpesvirus 1]] | ||
| + | [[Category: Human alphaherpesvirus 1 strain 17]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baldock C]] | ||
| + | [[Category: Golovanov AP]] | ||
| + | [[Category: Jowitt TA]] | ||
| + | [[Category: Levy C]] | ||
| + | [[Category: Lockhart-Cairns MP]] | ||
| + | [[Category: Mould P]] | ||
| + | [[Category: Sandri-Goldin RM]] | ||
| + | [[Category: Sito H]] | ||
| + | [[Category: Tunnicliffe RB]] | ||
Current revision
ICP4 DNA-binding domain, lacking intrinsically disordered region, in complex with 12mer DNA duplex from its own promoter
| |||||||||||
