This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5tut

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 5tut is ON HOLD until Paper Publication Authors: Sanchez, J.G., Wagner, J.M., Pornillos, O. Description: UbcH5a-Ub isopeptide conjugate [[Category:...)
Current revision (13:12, 4 October 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5tut is ON HOLD until Paper Publication
+
==UbcH5a-Ub isopeptide conjugate==
 +
<StructureSection load='5tut' size='340' side='right'caption='[[5tut]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5tut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TUT FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.604&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tut OCA], [https://pdbe.org/5tut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tut RCSB], [https://www.ebi.ac.uk/pdbsum/5tut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tut ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UB2D1_HUMAN UB2D1_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.<ref>PMID:18042044</ref> <ref>PMID:18359941</ref> <ref>PMID:19103148</ref> <ref>PMID:19854139</ref> <ref>PMID:20061386</ref>
-
Authors: Sanchez, J.G., Wagner, J.M., Pornillos, O.
+
==See Also==
-
 
+
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
-
Description: UbcH5a-Ub isopeptide conjugate
+
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
-
[[Category: Unreleased Structures]]
+
== References ==
-
[[Category: Pornillos, O]]
+
<references/>
-
[[Category: Wagner, J.M]]
+
__TOC__
-
[[Category: Sanchez, J.G]]
+
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Pornillos O]]
 +
[[Category: Sanchez JG]]
 +
[[Category: Wagner JM]]

Current revision

UbcH5a-Ub isopeptide conjugate

PDB ID 5tut

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5tut"
Personal tools