5u1s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Saccharomyces cerevisiae separase-securin complex at 3.0 angstrom resolution== | |
| - | + | <StructureSection load='5u1s' size='340' side='right'caption='[[5u1s]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5u1s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U1S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.002Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u1s OCA], [https://pdbe.org/5u1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u1s RCSB], [https://www.ebi.ac.uk/pdbsum/5u1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u1s ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ESP1_YEAST ESP1_YEAST] Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the MCD1/SCC1 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/PDS1 protein. It also promotes anaphase spindle elongation. A component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Cleaves SLK19.<ref>PMID:10403247</ref> <ref>PMID:11149918</ref> <ref>PMID:11832211</ref> <ref>PMID:9635435</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Luo S]] | ||
| + | [[Category: Tong L]] | ||
Current revision
Crystal structure of the Saccharomyces cerevisiae separase-securin complex at 3.0 angstrom resolution
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