5u27
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5u27 is ON HOLD Authors: SSGCID, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal Structure of Mycobacterium...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor== | |
| + | <StructureSection load='5u27' size='340' side='right'caption='[[5u27]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5u27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U27 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=P65:2,4-DIAMINO-6-METHYL-5-[3-(2,4,5-TRICHLOROPHENOXY)PROPYLOXY]PYRIMIDINE'>P65</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u27 OCA], [https://pdbe.org/5u27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u27 RCSB], [https://www.ebi.ac.uk/pdbsum/5u27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u27 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Mycobacterium tuberculosis]] | ||
Current revision
Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor
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