1qcr

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[[Image:1qcr.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY==
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|PDB= 1qcr |SIZE=350|CAPTION= <scene name='initialview01'>1qcr</scene>, resolution 2.7&Aring;
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<StructureSection load='1qcr' size='340' side='right'caption='[[1qcr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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<table><tr><td colspan='2'>[[1qcr]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QCR FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcr OCA], [https://pdbe.org/1qcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qcr RCSB], [https://www.ebi.ac.uk/pdbsum/1qcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qcr ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcr OCA], [http://www.ebi.ac.uk/pdbsum/1qcr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qcr RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/QCR1_BOVIN QCR1_BOVIN] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/1qcr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qcr ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY'''
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==See Also==
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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*[[Cytochrome bc1 3D structures|Cytochrome bc1 3D structures]]
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==Overview==
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__TOC__
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On the basis of x-ray diffraction data to a resolution of 2.9 angstroms, atomic models of most protein components of the bovine cytochrome bc1 complex were built, including core 1, core 2, cytochrome b, subunit 6, subunit 7, a carboxyl-terminal fragment of cytochrome c1, and an amino-terminal fragment of the iron-sulfur protein. The positions of the four iron centers within the bc1 complex and the binding sites of the two specific respiratory inhibitors antimycin A and myxothiazol were identified. The membrane-spanning region of each bc1 complex monomer consists of 13 transmembrane helices, eight of which belong to cytochrome b. Closely interacting monomers are arranged as symmetric dimers and form cavities through which the inhibitor binding pockets can be accessed. The proteins core 1 and core 2 are structurally similar to each other and consist of two domains of roughly equal size and identical folding topology.
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</StructureSection>
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==About this Structure==
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1QCR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCR OCA].
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==Reference==
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Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria., Xia D, Yu CA, Kim H, Xia JZ, Kachurin AM, Zhang L, Yu L, Deisenhofer J, Science. 1997 Jul 4;277(5322):60-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9204897 9204897]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Ubiquinol--cytochrome-c reductase]]
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[[Category: Deisenhofer J]]
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[[Category: Deisenhofer, J.]]
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[[Category: Kachurin A]]
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[[Category: Kachurin, A.]]
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[[Category: Kim H]]
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[[Category: Kim, H.]]
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[[Category: Xia D]]
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[[Category: Xia, D.]]
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[[Category: Xia JZ]]
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[[Category: Xia, J Z.]]
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[[Category: Yu CA]]
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[[Category: Yu, C A.]]
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[[Category: Yu L]]
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[[Category: Yu, L.]]
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[[Category: Zhang L]]
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[[Category: Zhang, L.]]
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[[Category: bc1]]
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[[Category: cytochrome b]]
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[[Category: cytochrome c1]]
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[[Category: electron transfer]]
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[[Category: iron sulfer protein]]
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[[Category: membrane protein]]
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[[Category: mitochondrial processing peptidase]]
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[[Category: mpp]]
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[[Category: oxidoreductase]]
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[[Category: protease]]
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[[Category: proton translocation]]
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[[Category: qcr]]
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[[Category: rieske]]
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[[Category: structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:11:55 2008''
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Current revision

CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY

PDB ID 1qcr

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