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5lsk

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==CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE MIS12-CENP-C COMPLEX==
==CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE MIS12-CENP-C COMPLEX==
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<StructureSection load='5lsk' size='340' side='right' caption='[[5lsk]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='5lsk' size='340' side='right'caption='[[5lsk]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lsk]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LSK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lsk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LSK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsk OCA], [http://pdbe.org/5lsk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lsk RCSB], [http://www.ebi.ac.uk/pdbsum/5lsk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsk ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.502&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsk OCA], [https://pdbe.org/5lsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lsk RCSB], [https://www.ebi.ac.uk/pdbsum/5lsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NSL1_HUMAN NSL1_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<ref>PMID:16585270</ref> [[http://www.uniprot.org/uniprot/MIS12_HUMAN MIS12_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108).<ref>PMID:12515822</ref> <ref>PMID:15502821</ref> <ref>PMID:16585270</ref> <ref>PMID:23891108</ref> [[http://www.uniprot.org/uniprot/DSN1_HUMAN DSN1_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<ref>PMID:15502821</ref> <ref>PMID:16585270</ref> [[http://www.uniprot.org/uniprot/PMF1_HUMAN PMF1_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.<ref>PMID:10419538</ref> <ref>PMID:11256947</ref> <ref>PMID:15502821</ref> <ref>PMID:16585270</ref> [[http://www.uniprot.org/uniprot/CENPC_HUMAN CENPC_HUMAN]] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.<ref>PMID:19482874</ref> <ref>PMID:21529714</ref>
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[https://www.uniprot.org/uniprot/MIS12_HUMAN MIS12_HUMAN] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108).<ref>PMID:12515822</ref> <ref>PMID:15502821</ref> <ref>PMID:16585270</ref> <ref>PMID:23891108</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5lsk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lsk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Keller, J]]
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[[Category: Homo sapiens]]
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[[Category: Liu, Y]]
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[[Category: Large Structures]]
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[[Category: Petrovic, A]]
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[[Category: Keller J]]
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[[Category: Vetter, I R]]
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[[Category: Liu Y]]
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[[Category: Alpha-helical]]
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[[Category: Petrovic A]]
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[[Category: Cell cycle]]
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[[Category: Vetter IR]]

Current revision

CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE MIS12-CENP-C COMPLEX

PDB ID 5lsk

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