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5h5q

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==Crystal structure of human GPX4 in complex with GXpep-1==
==Crystal structure of human GPX4 in complex with GXpep-1==
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<StructureSection load='5h5q' size='340' side='right' caption='[[5h5q]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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<StructureSection load='5h5q' size='340' side='right'caption='[[5h5q]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h5q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H5Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H5Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h5r|5h5r]], [[5h5s|5h5s]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h5q OCA], [https://pdbe.org/5h5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h5q RCSB], [https://www.ebi.ac.uk/pdbsum/5h5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h5q ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h5q OCA], [http://pdbe.org/5h5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h5q RCSB], [http://www.ebi.ac.uk/pdbsum/5h5q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h5q ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN]] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
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[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5h5q" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5h5q" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutathione peroxidase|Glutathione peroxidase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Phospholipid-hydroperoxide glutathione peroxidase]]
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[[Category: Escherichia phage T7]]
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[[Category: Kadotani, A]]
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[[Category: Homo sapiens]]
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[[Category: Lane, W]]
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[[Category: Large Structures]]
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[[Category: Snell, G]]
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[[Category: Kadotani A]]
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[[Category: Sogabe, S]]
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[[Category: Lane W]]
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[[Category: Oxidoreductase]]
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[[Category: Snell G]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Sogabe S]]
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[[Category: Phospholipid hydroperoxide glutathione peroxidase 4]]
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[[Category: Selenocysteine]]
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Current revision

Crystal structure of human GPX4 in complex with GXpep-1

PDB ID 5h5q

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