5egr
From Proteopedia
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==tRNA guanine transglycosylase (TGT) in complex with an Immucillin derivative== | ==tRNA guanine transglycosylase (TGT) in complex with an Immucillin derivative== | ||
| - | <StructureSection load='5egr' size='340' side='right' caption='[[5egr]], [[Resolution|resolution]] 1.55Å' scene=''> | + | <StructureSection load='5egr' size='340' side='right'caption='[[5egr]], [[Resolution|resolution]] 1.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5egr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGR OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5egr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EGR FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5NT:2-AZANYL-7-[(2~{S},3~{R},5~{S})-5-(HYDROXYMETHYL)-3-OXIDANYL-PYRROLIDIN-2-YL]-3,5-DIHYDROPYRROLO[3,2-D]PYRIMIDIN-4-ONE'>5NT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NT:2-AZANYL-7-[(2~{S},3~{R},5~{S})-5-(HYDROXYMETHYL)-3-OXIDANYL-PYRROLIDIN-2-YL]-3,5-DIHYDROPYRROLO[3,2-D]PYRIMIDIN-4-ONE'>5NT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5egr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5egr OCA], [https://pdbe.org/5egr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5egr RCSB], [https://www.ebi.ac.uk/pdbsum/5egr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5egr ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] |
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| + | ==See Also== | ||
| + | *[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]] |
| - | [[Category: | + | [[Category: Ehrmann FR]] |
| - | [[Category: | + | [[Category: Heine A]] |
| - | [[Category: | + | [[Category: Klebe G]] |
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Current revision
tRNA guanine transglycosylase (TGT) in complex with an Immucillin derivative
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