1qf5

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[[Image:1qf5.jpg|left|200px]]
 
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{{Structure
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==DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE==
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|PDB= 1qf5 |SIZE=350|CAPTION= <scene name='initialview01'>1qf5</scene>, resolution 2.0&Aring;
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<StructureSection load='1qf5' size='340' side='right'caption='[[1qf5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RPL:(C8-S)-HYDANTOCIDIN+5&#39;-PHOSPHATE'>RPL</scene>
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<table><tr><td colspan='2'>[[1qf5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QF5 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RPL:(C8-S)-HYDANTOCIDIN+5-PHOSPHATE'>RPL</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qf5 OCA], [https://pdbe.org/1qf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qf5 RCSB], [https://www.ebi.ac.uk/pdbsum/1qf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qf5 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1qf4|1QF4]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qf5 OCA], [http://www.ebi.ac.uk/pdbsum/1qf5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qf5 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PURA_ECOLI PURA_ECOLI] Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).[HAMAP-Rule:MF_00011]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/1qf5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qf5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
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'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''
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An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase.,Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888<ref>PMID:10556888</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1qf5" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
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*[[Adenylosuccinate synthetase 3D structures|Adenylosuccinate synthetase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1QF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF5 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10556888 10556888]
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[[Category: Adenylosuccinate synthase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chemla, P.]]
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[[Category: Chemla P]]
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[[Category: Cowan-Jacob, S W.]]
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[[Category: Cowan-Jacob SW]]
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[[Category: Fonne-Pfister, R.]]
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[[Category: Fonne-Pfister R]]
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[[Category: Gohda, K.]]
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[[Category: Gohda K]]
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[[Category: Hanessian, S.]]
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[[Category: Hanessian S]]
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[[Category: Lu, P P.]]
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[[Category: Lu P-P]]
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[[Category: Prade, L.]]
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[[Category: Prade L]]
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[[Category: Sanceau, J Y.]]
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[[Category: Sanceau J-Y]]
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[[Category: gtp-binding]]
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[[Category: gtp-hydrolysing enzyme]]
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[[Category: purine biosynthesis]]
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[[Category: synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:38 2008''
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Current revision

DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE

PDB ID 1qf5

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