5sy7

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==Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA==
==Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA==
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<StructureSection load='5sy7' size='340' side='right' caption='[[5sy7]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
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<StructureSection load='5sy7' size='340' side='right'caption='[[5sy7]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5sy7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SY7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5sy7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SY7 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5sy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy7 OCA], [http://pdbe.org/5sy7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sy7 RCSB], [http://www.ebi.ac.uk/pdbsum/5sy7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy7 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy7 OCA], [https://pdbe.org/5sy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sy7 RCSB], [https://www.ebi.ac.uk/pdbsum/5sy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). [[http://www.uniprot.org/uniprot/NPAS3_MOUSE NPAS3_MOUSE]] May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.<ref>PMID:15347806</ref>
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[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5sy7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5sy7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kim, Y]]
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[[Category: Large Structures]]
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[[Category: Potluri, N]]
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[[Category: Mus musculus]]
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[[Category: Rastinejad, F]]
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[[Category: Kim Y]]
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[[Category: Su, X]]
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[[Category: Potluri N]]
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[[Category: Wu, D]]
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[[Category: Rastinejad F]]
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[[Category: Bhlh-pas protein]]
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[[Category: Su X]]
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[[Category: Heterodimeric complex]]
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[[Category: Wu D]]
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[[Category: Transcription factor]]
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[[Category: Transcription-dna complex]]
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Current revision

Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA

PDB ID 5sy7

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