1qg9
From Proteopedia
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| - | [[Image:1qg9.gif|left|200px]] | ||
| - | + | ==SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL== | |
| - | + | <StructureSection load='1qg9' size='340' side='right'caption='[[1qg9]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1qg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QG9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | | | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qg9 OCA], [https://pdbe.org/1qg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qg9 RCSB], [https://www.ebi.ac.uk/pdbsum/1qg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qg9 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/SCN3A_RAT SCN3A_RAT] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | |
| - | + | <div style="background-color:#fffaf0;"> | |
| - | + | == Publication Abstract from PubMed == | |
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Peptides representing transmembrane regions of the alpha-subunit of the voltage-gated sodium channel were synthesised and their structures analysed, using 1H NMR and CD, in trifluoroethanol and in dodecylphosphocholine micelles. Sequence analysis suggests that the channel has six regions, S1 to S6, predicted to span the membrane in four homologous domains, designated, I, II, III and IV. Presented here are studies of representatives examples of possible single spanning segments (IS2, IS4, IVS4) and a double spanning segment, IS34, composed of segments IS3 and IS4. In addition, we investigated ISlink56, the putative linker region between segments IS5 and IS6. All of the peptides were found to have predominantly alpha-helical structures in both solvent systems. There was some evidence for bending of the longer helices but there was no discernible evidence for well-defined tertiary structure. | Peptides representing transmembrane regions of the alpha-subunit of the voltage-gated sodium channel were synthesised and their structures analysed, using 1H NMR and CD, in trifluoroethanol and in dodecylphosphocholine micelles. Sequence analysis suggests that the channel has six regions, S1 to S6, predicted to span the membrane in four homologous domains, designated, I, II, III and IV. Presented here are studies of representatives examples of possible single spanning segments (IS2, IS4, IVS4) and a double spanning segment, IS34, composed of segments IS3 and IS4. In addition, we investigated ISlink56, the putative linker region between segments IS5 and IS6. All of the peptides were found to have predominantly alpha-helical structures in both solvent systems. There was some evidence for bending of the longer helices but there was no discernible evidence for well-defined tertiary structure. | ||
| - | + | Structural studies of synthetic peptides dissected from the voltage-gated sodium channel.,Doak DG, Mulvey D, Kawaguchi K, Villalain J, Campbell ID J Mol Biol. 1996 May 17;258(4):672-87. PMID:8637001<ref>PMID:8637001</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1qg9" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Campbell ID]] | ||
| + | [[Category: Doak DJ]] | ||
| + | [[Category: Kawaguchi K]] | ||
| + | [[Category: Mulvey D]] | ||
| + | [[Category: Villalain J]] | ||
Current revision
SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL
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