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5e1g

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==Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T208==
==Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T208==
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<StructureSection load='5e1g' size='340' side='right' caption='[[5e1g]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='5e1g' size='340' side='right'caption='[[5e1g]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5e1g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E1G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5e1g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E1G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T8G:(2~{S},3~{R},4~{R})-4-(2-CYCLOHEXYLOXY-2-OXIDANYLIDENE-ETHYL)SULFANYL-3-METHYL-2-[(2~{S},3~{R})-3-OXIDANYL-1-OXIDANYLIDENE-BUTAN-2-YL]-3,4-DIHYDRO-2~{H}-PYRROLE-5-CARBOXYLIC+ACID'>T8G</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.852&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dzp|5dzp]], [[5dzj|5dzj]], [[5e1i|5e1i]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T8G:(2~{S},3~{R},4~{R})-4-(2-CYCLOHEXYLOXY-2-OXIDANYLIDENE-ETHYL)SULFANYL-3-METHYL-2-[(2~{S},3~{R})-3-OXIDANYL-1-OXIDANYLIDENE-BUTAN-2-YL]-3,4-DIHYDRO-2~{H}-PYRROLE-5-CARBOXYLIC+ACID'>T8G</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1g OCA], [http://pdbe.org/5e1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e1g RCSB], [http://www.ebi.ac.uk/pdbsum/5e1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1g OCA], [https://pdbe.org/5e1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e1g RCSB], [https://www.ebi.ac.uk/pdbsum/5e1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>
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[https://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ginell, S L]]
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[[Category: Large Structures]]
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[[Category: Kumar, P]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Lamichhane, G]]
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[[Category: Ginell SL]]
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[[Category: Cell wall enzyme]]
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[[Category: Kumar P]]
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[[Category: Peptidoglycan synthesis enzyme]]
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[[Category: Lamichhane G]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T208

PDB ID 5e1g

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