5kod

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==Crystal Structure of GH3.5 Acyl Acid Amido Synthetase from Arabidopsis thaliana==
==Crystal Structure of GH3.5 Acyl Acid Amido Synthetase from Arabidopsis thaliana==
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<StructureSection load='5kod' size='340' side='right' caption='[[5kod]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5kod' size='340' side='right'caption='[[5kod]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kod]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KOD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kod]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KOD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=IAC:1H-INDOL-3-YLACETIC+ACID'>IAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.202&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kod OCA], [http://pdbe.org/5kod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kod RCSB], [http://www.ebi.ac.uk/pdbsum/5kod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kod ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=IAC:1H-INDOL-3-YLACETIC+ACID'>IAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kod OCA], [https://pdbe.org/5kod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kod RCSB], [https://www.ebi.ac.uk/pdbsum/5kod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kod ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GH35_ARATH GH35_ARATH]] Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin. Strongly reactive with Glu, Gln, Trp, Asp, Ala, Leu, Phe, Gly, Tyr, Met, Ile and Val. Little or no product formation with His, Ser, Thr, Arg, Lys, or Cys. Also active on pyruvic and butyric acid analogs of IAA, PAA and the synthetic auxin naphthaleneacetic acid (NAA). The two chlorinated synthetic auxin herbicides 2,4-D and 3,6-dichloro-o-anisic acid (dicamba) cannot be used as substrates.<ref>PMID:15659623</ref>
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[https://www.uniprot.org/uniprot/GH35_ARATH GH35_ARATH] Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin. Strongly reactive with Glu, Gln, Trp, Asp, Ala, Leu, Phe, Gly, Tyr, Met, Ile and Val. Little or no product formation with His, Ser, Thr, Arg, Lys, or Cys. Also active on pyruvic and butyric acid analogs of IAA, PAA and the synthetic auxin naphthaleneacetic acid (NAA). The two chlorinated synthetic auxin herbicides 2,4-D and 3,6-dichloro-o-anisic acid (dicamba) cannot be used as substrates.<ref>PMID:15659623</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5kod" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5kod" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Renin|Renin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Jez, J M]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Westfall, C S]]
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[[Category: Large Structures]]
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[[Category: Zubieta, C]]
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[[Category: Jez JM]]
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[[Category: Acyl acid amido synthetase]]
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[[Category: Westfall CS]]
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[[Category: Adenylating enzyme]]
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[[Category: Zubieta C]]
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[[Category: Adenylation ligase]]
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[[Category: Anl]]
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[[Category: Ligase]]
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Current revision

Crystal Structure of GH3.5 Acyl Acid Amido Synthetase from Arabidopsis thaliana

PDB ID 5kod

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