3nia

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==GES-2 carbapenemase tazobactam complex==
==GES-2 carbapenemase tazobactam complex==
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<StructureSection load='3nia' size='340' side='right' caption='[[3nia]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='3nia' size='340' side='right'caption='[[3nia]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nia]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NIA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NIA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBE:TAZOBACTAM+INTERMEDIATE'>TBE</scene>, <scene name='pdbligand=TF7:(3S)-3-(DIHYDROXY-LAMBDA~4~-SULFANYL)-4-(1H-1,2,3-TRIAZOL-1-YL)-D-VALINE'>TF7</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ni9|3ni9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TBE:TAZOBACTAM+INTERMEDIATE'>TBE</scene>, <scene name='pdbligand=TF7:(3S)-3-(DIHYDROXY-LAMBDA~4~-SULFANYL)-4-(1H-1,2,3-TRIAZOL-1-YL)-D-VALINE'>TF7</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla GES-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nia OCA], [https://pdbe.org/3nia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nia RCSB], [https://www.ebi.ac.uk/pdbsum/3nia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nia ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nia OCA], [http://pdbe.org/3nia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nia RCSB], [http://www.ebi.ac.uk/pdbsum/3nia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nia ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAG2_PSEAI BLAG2_PSEAI] Extended-spectrum beta-lactamase (ESBL) which confers resistance to penicillins, as well as first, third and fourth-generation cephalosporins (PubMed:11502535, PubMed:19656947, PubMed:20696873, PubMed:21220532). Has modest carbapenem-hydrolyzing activity (PubMed:11502535, PubMed:19656947, PubMed:25485972). Has cefotaxime-hydrolyzing activity (PubMed:11502535, PubMed:19656947).<ref>PMID:11502535</ref> <ref>PMID:19656947</ref> <ref>PMID:20696873</ref> <ref>PMID:21220532</ref> <ref>PMID:25485972</ref>
==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Frase, H]]
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[[Category: Large Structures]]
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[[Category: Smith, C A]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Toth, M]]
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[[Category: Frase H]]
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[[Category: Vakulenko, S B]]
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[[Category: Smith CA]]
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[[Category: Antibiotic resistance]]
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[[Category: Toth M]]
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[[Category: Beta-lactamase]]
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[[Category: Vakulenko SB]]
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[[Category: Carbapenemase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Lactamase inhibitor]]
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Current revision

GES-2 carbapenemase tazobactam complex

PDB ID 3nia

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