We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

5glj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:12, 20 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal Structure of PDZ1 Domain of Human Protein Tyrosine Phosphatase PTP-Bas==
==Crystal Structure of PDZ1 Domain of Human Protein Tyrosine Phosphatase PTP-Bas==
-
<StructureSection load='5glj' size='340' side='right' caption='[[5glj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+
<StructureSection load='5glj' size='340' side='right'caption='[[5glj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5glj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GLJ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5glj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GLJ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5glj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glj OCA], [http://pdbe.org/5glj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5glj RCSB], [http://www.ebi.ac.uk/pdbsum/5glj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5glj ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5glj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glj OCA], [https://pdbe.org/5glj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5glj RCSB], [https://www.ebi.ac.uk/pdbsum/5glj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5glj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PTN13_HUMAN PTN13_HUMAN]] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.<ref>PMID:15611135</ref>
+
[https://www.uniprot.org/uniprot/PTN13_HUMAN PTN13_HUMAN] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.<ref>PMID:15611135</ref>
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Protein tyrosine phosphatase-Basophil (PTP-Bas) is a membrane-associated protein tyrosine phosphatase with five PDZ domains and is involved in apoptosis, tumorigenesis, and insulin signaling. The interaction between PTP-Bas and tandem-PH-domain-containing protein 1/2 (TAPP1/2) plays an essential role in the regulation of insulin signaling. Despite its high sequence homology with the other PDZ domains, only the PDZ1 domain of PTP-Bas showed distinct binding specificity for TAPP1/2. Although the interaction between PTP-Bas PDZ1 and TAPP1/2 is a therapeutic target for diabetes, the structural basis for the interaction has not been elucidated. In the present study, we determined the crystal structure of the PTP-Bas PDZ1 domain at 1.6 A resolution. In addition, we calculated the structural models of complexes of PTP-Bas PDZ1 and the C-terminal peptides of TAPP1/2 (referred to as TAPP1p/2p). Structural comparison with the PTP-Bas PDZ2/RA-GEF2 peptide complex revealed a structural basis for distinct binding specificity of PTP-Bas PDZ1 for TAPP1p/2p peptides. Our high-resolution crystal structure of PTP-Bas PDZ1 will serve as a useful template for rational structure-based design of novel anti-diabetes therapeutics.
+
-
 
+
-
High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas.,Lee SO, Lee MK, Ku B, Bae KH, Lee SC, Lim HM, Kim SJ, Chi SW Biochem Biophys Res Commun. 2016 Sep 23;478(3):1205-10. doi:, 10.1016/j.bbrc.2016.08.095. Epub 2016 Aug 18. PMID:27544031<ref>PMID:27544031</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 5glj" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
-
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Protein-tyrosine-phosphatase]]
+
[[Category: Homo sapiens]]
-
[[Category: Chi, S W]]
+
[[Category: Large Structures]]
-
[[Category: Ku, B]]
+
[[Category: Chi SW]]
-
[[Category: Lee, S O]]
+
[[Category: Ku B]]
-
[[Category: Hydrolase]]
+
[[Category: Lee SO]]
-
[[Category: Pdz1 domain]]
+
-
[[Category: Ptp-ba]]
+

Current revision

Crystal Structure of PDZ1 Domain of Human Protein Tyrosine Phosphatase PTP-Bas

PDB ID 5glj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5glj"
Personal tools