This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3t24

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:15, 14 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of Pseudomonas aeruginosa OpdQ==
==Crystal structure of Pseudomonas aeruginosa OpdQ==
-
<StructureSection load='3t24' size='340' side='right' caption='[[3t24]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+
<StructureSection load='3t24' size='340' side='right'caption='[[3t24]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3t24]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T24 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3t24]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T24 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sy7|3sy7]], [[3sy9|3sy9]], [[3syb|3syb]], [[3sys|3sys]], [[3szd|3szd]], [[3szv|3szv]], [[3t0s|3t0s]], [[3t20|3t20]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA3038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t24 OCA], [https://pdbe.org/3t24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t24 RCSB], [https://www.ebi.ac.uk/pdbsum/3t24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t24 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t24 OCA], [http://pdbe.org/3t24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t24 RCSB], [http://www.ebi.ac.uk/pdbsum/3t24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t24 ProSAT]</span></td></tr>
+
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/Q9HZH0_PSEAE Q9HZH0_PSEAE]
-
Many Gram-negative bacteria, including human pathogens such as Pseudomonas aeruginosa, do not have large-channel porins. This results in an outer membrane (OM) that is highly impermeable to small polar molecules, making the bacteria intrinsically resistant towards many antibiotics. In such microorganisms, the majority of small molecules are taken up by members of the OprD outer membrane protein family. Here we show that OprD channels require a carboxyl group in the substrate for efficient transport, and based on this we have renamed the family Occ, for outer membrane carboxylate channels. We further show that Occ channels can be divided into two subfamilies, based on their very different substrate specificities. Our results rationalize how certain bacteria can efficiently take up a variety of substrates under nutrient-poor conditions without compromising membrane permeability. In addition, they explain how channel inactivation in response to antibiotics can cause resistance but does not lead to decreased fitness.
+
-
 
+
-
Substrate Specificity within a Family of Outer Membrane Carboxylate Channels.,Eren E, Vijayaraghavan J, Liu J, Cheneke BR, Touw DS, Lepore BW, Indic M, Movileanu L, van den Berg B PLoS Biol. 2012 Jan;10(1):e1001242. Epub 2012 Jan 17. PMID:22272184<ref>PMID:22272184</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 3t24" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
-
*[[Porin|Porin]]
+
*[[Porin 3D structures|Porin 3D structures]]
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Berg, B van den]]
+
[[Category: Large Structures]]
-
[[Category: Eren, E]]
+
[[Category: Pseudomonas aeruginosa]]
-
[[Category: Bacterial outer membrane]]
+
[[Category: Eren E]]
-
[[Category: Beta-barrel]]
+
[[Category: Van den Berg B]]
-
[[Category: Channel]]
+
-
[[Category: Membrane protein]]
+

Current revision

Crystal structure of Pseudomonas aeruginosa OpdQ

PDB ID 3t24

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3t24"
Personal tools