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3qav

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==Crystal structure of a glutathione S-transferase from Antarctic clam Laternula elliptica==
==Crystal structure of a glutathione S-transferase from Antarctic clam Laternula elliptica==
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<StructureSection load='3qav' size='340' side='right' caption='[[3qav]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3qav' size='340' side='right'caption='[[3qav]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qav]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Laternula_elliptica Laternula elliptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QAV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qav]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Laternula_elliptica Laternula elliptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QAV FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qaw|3qaw]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qav OCA], [https://pdbe.org/3qav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qav RCSB], [https://www.ebi.ac.uk/pdbsum/3qav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qav ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qav OCA], [http://pdbe.org/3qav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qav RCSB], [http://www.ebi.ac.uk/pdbsum/3qav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qav ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/B9VX79_LATEL B9VX79_LATEL]
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Glutathione-S-transferases have been identified in all the living species examined so far, yet little is known about their function in marine organisms. In a previous report, the recently identified GST from Antarctic bivalve Laternula elliptica (LeGST) was classified into the rho class GST, but there are several unique features of LeGST that may justify reclassification, which could represent specific shellfish GSTs. Here, we determined the crystal structure of LeGST, which is a shellfish specific class of GST. The structural analysis showed that the relatively open and wide hydrophobic H-site of the LeGST allows this GST to accommodate various substrates. These results suggest that the H-site of LeGST may be the result of adaptation to their environments as sedentary organisms. Proteins 2013. (c) 2012 Wiley Periodicals, Inc.
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The structure of a shellfish specific GST class glutathione S-transferase from antarctic bivalve Laternula elliptica reveals novel active site architecture.,Park AK, Moon JH, Jang EH, Park H, Ahn IY, Lee KS, Chi YM Proteins. 2013 Mar;81(3):531-7. doi: 10.1002/prot.24208. Epub 2012 Dec 24. PMID:23152139<ref>PMID:23152139</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qav" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Glutathione S-transferase|Glutathione S-transferase]]
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glutathione transferase]]
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[[Category: Large Structures]]
[[Category: Laternula elliptica]]
[[Category: Laternula elliptica]]
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[[Category: Chi, Y M]]
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[[Category: Chi YM]]
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[[Category: Moon, J H]]
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[[Category: Moon JH]]
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[[Category: Park, A K]]
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[[Category: Park AK]]
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[[Category: Cytosol]]
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[[Category: Transferase]]
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Current revision

Crystal structure of a glutathione S-transferase from Antarctic clam Laternula elliptica

PDB ID 3qav

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