3q82

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==Meropenem acylated BlaR1 sensor domain from Staphylococcus aureus==
==Meropenem acylated BlaR1 sensor domain from Staphylococcus aureus==
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<StructureSection load='3q82' size='340' side='right' caption='[[3q82]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3q82' size='340' side='right'caption='[[3q82]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3q82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q82 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3q82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q82 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MER:(4R,5S)-3-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-5-[(2S,3R)-3-HYDROXY-1-OXOBUTAN-2-YL]-4-METHYL-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>MER</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xa1|1xa1]], [[3q7v|3q7v]], [[3q7z|3q7z]], [[3q81|3q81]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MER:(4R,5S)-3-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-5-[(2S,3R)-3-HYDROXY-1-OXOBUTAN-2-YL]-4-METHYL-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>MER</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaR1, VRA0048 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q82 OCA], [https://pdbe.org/3q82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q82 RCSB], [https://www.ebi.ac.uk/pdbsum/3q82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q82 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q82 OCA], [http://pdbe.org/3q82 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q82 RCSB], [http://www.ebi.ac.uk/pdbsum/3q82 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q82 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAR_STAAU BLAR_STAAU] BlaR1 is a potential penicillin-binding protein required for induction of beta-lactamase.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker, B M]]
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[[Category: Large Structures]]
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[[Category: Borbulevych, O Y]]
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[[Category: Staphylococcus aureus]]
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[[Category: Mobashery, S]]
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[[Category: Baker BM]]
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[[Category: Antibiotic-binding]]
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[[Category: Borbulevych OY]]
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[[Category: Antibiotic-binding-antibiotic complex]]
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[[Category: Mobashery S]]
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[[Category: Hydrolase regulator-antibiotic complex]]
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[[Category: Mrsa]]
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Current revision

Meropenem acylated BlaR1 sensor domain from Staphylococcus aureus

PDB ID 3q82

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