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1qnf

From Proteopedia

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[[Image:1qnf.gif|left|200px]]
 
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{{Structure
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==STRUCTURE OF PHOTOLYASE==
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|PDB= 1qnf |SIZE=350|CAPTION= <scene name='initialview01'>1qnf</scene>, resolution 1.8&Aring;
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<StructureSection load='1qnf' size='340' side='right'caption='[[1qnf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HDF:8-HYDROXY-10-(D-RIBO-2,3,4,5-TETRAHYDROXYPENTYL)-5-DEAZAISOALLOXAZINE'>HDF</scene>
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<table><tr><td colspan='2'>[[1qnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_6301 Synechococcus elongatus PCC 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNF FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribodipyrimidine_photo-lyase Deoxyribodipyrimidine photo-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.99.3 4.1.99.3] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HDF:8-HYDROXY-10-(D-RIBO-2,3,4,5-TETRAHYDROXYPENTYL)-5-DEAZAISOALLOXAZINE'>HDF</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnf OCA], [https://pdbe.org/1qnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnf RCSB], [https://www.ebi.ac.uk/pdbsum/1qnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnf ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnf OCA], [http://www.ebi.ac.uk/pdbsum/1qnf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qnf RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PHR_SYNP6 PHR_SYNP6] Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
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== Evolutionary Conservation ==
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'''STRUCTURE OF PHOTOLYASE'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnf_consurf.spt"</scriptWhenChecked>
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The crystal structure at 1.8 A resolution of 8-HDF type photolyase from A. nidulans shows a backbone structure similar to that of MTHF type E. coli photolyase but reveals a completely different binding site for the light-harvesting cofactor.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1QNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNF OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnf ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of DNA photolyase from Anacystis nidulans., Tamada T, Kitadokoro K, Higuchi Y, Inaka K, Yasui A, de Ruiter PE, Eker AP, Miki K, Nat Struct Biol. 1997 Nov;4(11):887-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9360600 9360600]
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</StructureSection>
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[[Category: Deoxyribodipyrimidine photo-lyase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Synechococcus elongatus PCC 6301]]
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[[Category: Synechococcus sp.]]
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[[Category: Kitadokoro K]]
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[[Category: Kitadokoro, K.]]
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[[Category: Miki K]]
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[[Category: Miki, K.]]
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[[Category: dna repair]]
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[[Category: electron transfer]]
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[[Category: excitation energy transfer]]
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[[Category: lyase (carbon-carbon)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:16:15 2008''
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Current revision

STRUCTURE OF PHOTOLYASE

PDB ID 1qnf

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