5dij

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==The crystal structure of CT==
==The crystal structure of CT==
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<StructureSection load='5dij' size='340' side='right' caption='[[5dij]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='5dij' size='340' side='right'caption='[[5dij]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dij]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DIJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Penicillium_aethiopicum Penicillium aethiopicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DIJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dij OCA], [http://pdbe.org/5dij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dij RCSB], [http://www.ebi.ac.uk/pdbsum/5dij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dij ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dij OCA], [https://pdbe.org/5dij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dij RCSB], [https://www.ebi.ac.uk/pdbsum/5dij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dij ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/F1CWE4_PENAE F1CWE4_PENAE]
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Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (CT) domain and the holo thiolation (T)-CT complex of Penicillium aethiopicum TqaA. The first, to our knowledge, structural depiction of the terminal module in a fungal NRPS provides a molecular blueprint for generating new macrocyclic peptide natural products.
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Structural basis of nonribosomal peptide macrocyclization in fungi.,Zhang J, Liu N, Cacho RA, Gong Z, Liu Z, Qin W, Tang C, Tang Y, Zhou J Nat Chem Biol. 2016 Dec;12(12):1001-1003. doi: 10.1038/nchembio.2202. Epub 2016, Oct 17. PMID:27748753<ref>PMID:27748753</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5dij" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Tang, Y]]
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[[Category: Large Structures]]
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[[Category: Zhang, J R]]
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[[Category: Penicillium aethiopicum]]
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[[Category: Zhou, J H]]
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[[Category: Tang Y]]
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[[Category: Biosynthesis]]
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[[Category: Zhang JR]]
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[[Category: Enzyme]]
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[[Category: Zhou JH]]
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[[Category: Unknown function]]
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Current revision

The crystal structure of CT

PDB ID 5dij

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