1qqe

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[[Image:1qqe.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17==
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|PDB= 1qqe |SIZE=350|CAPTION= <scene name='initialview01'>1qqe</scene>, resolution 2.90&Aring;
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<StructureSection load='1qqe' size='340' side='right'caption='[[1qqe]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQE FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [https://pdbe.org/1qqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [https://www.ebi.ac.uk/pdbsum/1qqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqe ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB]</span>
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[https://www.uniprot.org/uniprot/SEC17_YEAST SEC17_YEAST] SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion.<ref>PMID:8620540</ref> <ref>PMID:8670830</ref> <ref>PMID:9144293</ref> <ref>PMID:15889152</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqe_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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SNAP proteins play an essential role in membrane trafficking in eukaryotic cells. They activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF. We have determined the crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A resolution. Sec17 is composed of an N-terminal twisted sheet of alpha-helical hairpins and a C-terminal alpha-helical bundle. The N-terminal sheet has local similarity to the tetratricopeptide repeats from protein phosphatase 5 but has a different overall twist. Sec17 also shares structural features with HEAT and clathrin heavy chain repeats. Possible models of SNAP:SNARE binding suggest that SNAPs may function as lever arms, transmitting forces generated by conformational changes in NSF/Sec18 to drive disassembly of SNARE complexes.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqe ConSurf].
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1QQE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Crystal structure of the vesicular transport protein Sec17: implications for SNAP function in SNARE complex disassembly., Rice LM, Brunger AT, Mol Cell. 1999 Jul;4(1):85-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10445030 10445030]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Brunger AT]]
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[[Category: Brunger, A T.]]
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[[Category: Rice LM]]
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[[Category: Rice, L M.]]
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[[Category: helix-turn-helix tpr-like repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:17:29 2008''
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Current revision

CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17

PDB ID 1qqe

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