4don
From Proteopedia
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==Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon== | ==Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon== | ||
| - | <StructureSection load='4don' size='340' side='right' caption='[[4don]], [[Resolution|resolution]] 1.52Å' scene=''> | + | <StructureSection load='4don' size='340' side='right'caption='[[4don]], [[Resolution|resolution]] 1.52Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4don]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4don]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DON FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PF:3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>3PF</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4don FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4don OCA], [https://pdbe.org/4don PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4don RCSB], [https://www.ebi.ac.uk/pdbsum/4don PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4don ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). |
==See Also== | ==See Also== | ||
| - | *[[Bromodomain-containing protein|Bromodomain-containing protein]] | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Cao DY]] |
| - | [[Category: Chen | + | [[Category: Chen TT]] |
| - | [[Category: | + | [[Category: Chen WY]] |
| - | [[Category: | + | [[Category: Shen JK]] |
| - | [[Category: | + | [[Category: Xiong B]] |
| - | [[Category: | + | [[Category: Xu YC]] |
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Current revision
Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon
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Categories: Homo sapiens | Large Structures | Cao DY | Chen TT | Chen WY | Shen JK | Xiong B | Xu YC
