1qrq

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[[Image:1qrq.gif|left|200px]]
 
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{{Structure
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==STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT==
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|PDB= 1qrq |SIZE=350|CAPTION= <scene name='initialview01'>1qrq</scene>, resolution 2.80&Aring;
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<StructureSection load='1qrq' size='340' side='right'caption='[[1qrq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
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<table><tr><td colspan='2'>[[1qrq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QRQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qrq OCA], [https://pdbe.org/1qrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qrq RCSB], [https://www.ebi.ac.uk/pdbsum/1qrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qrq ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qrq OCA], [http://www.ebi.ac.uk/pdbsum/1qrq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qrq RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/KCAB2_RAT KCAB2_RAT] Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qrq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qrq ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT'''
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==See Also==
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*[[Ion channels|Ion channels]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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==Overview==
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__TOC__
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The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the beta subunit. One function of beta subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian beta subunits by X-ray crystallography at 2.8 A resolution. Like the integral membrane component of K+ channels, beta subunits form a four-fold symmetric structure. Each subunit is an oxidoreductase enzyme complete with a nicotinamide co-factor in its active site. Several structural features of the enzyme active site, including its location with respect to the four-fold axis, imply that it may interact directly or indirectly with the K+ channel's voltage sensor. This structure suggests a mechanism for coupling membrane electrical excitability directly to chemistry of the cell.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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1QRQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRQ OCA].
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==Reference==
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Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10399921 10399921]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Gulbis JM]]
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[[Category: Gulbis, J M.]]
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[[Category: MacKinnon R]]
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[[Category: MacKinnon, R.]]
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[[Category: Mann S]]
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[[Category: Mann, S.]]
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[[Category: aldo-keto reductase]]
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[[Category: metal transport]]
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[[Category: potassium channel subunit]]
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[[Category: tim barrel]]
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[[Category: voltage-dependent potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:18:05 2008''
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Current revision

STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT

PDB ID 1qrq

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