Vinculin
From Proteopedia
(Difference between revisions)
| (7 intermediate revisions not shown.) | |||
| Line 5: | Line 5: | ||
== Relevance == | == Relevance == | ||
Loss of VCL could be used as a prognostic factor for colorectal cancer se it promotes metastasis<ref>PMID:25496021</ref>. | Loss of VCL could be used as a prognostic factor for colorectal cancer se it promotes metastasis<ref>PMID:25496021</ref>. | ||
| + | |||
| + | == Disease == | ||
| + | Mutation in m-VCL can yield cardiomyopathic phenotype<ref>PMID:16236538</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
<scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. | <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. | ||
| - | + | ||
== 3D Structures of Vinculin == | == 3D Structures of Vinculin == | ||
| + | [[Vinculin 3D structures]] | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *Vinculin | ||
| - | |||
| - | **[[1tr2]] – hVCL - human<br /> | ||
| - | **[[1qkr]] – hVCL tail domain<br /> | ||
| - | **[[3h2v]] - hVCL tail domain + raver1 RRM<br /> | ||
| - | **[[4pr9]] - hVCL tail domain + lipid<br /> | ||
| - | **[[3jbi]] - hVCL tail domain + actin – Cryo-EM<br /> | ||
| - | **[[3h2u]] – hVCL Vd1 + raver1 RRM <br /> | ||
| - | **[[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from ''Shigella flexneri''<br /> | ||
| - | **[[1ydi]] - hVCL Vd1+hActinin VBS<br /> | ||
| - | **[[1t01]] - cVCL Vd1+mTalin VBS – chicken<br /> | ||
| - | **[[1syq]], [[1rkc]], [[1rke]] – hVCL Vd1+hTalin VBS<br /> | ||
| - | **[[3zdl]] – cVCL Vd1 + amyloid β precursor protein N terminal<br /> | ||
| - | |||
| - | *Metavinculin | ||
| - | |||
| - | **[[3myi]] – m-VCL tail domain <br /> | ||
| - | **[[5l0f]], [[5l0i]], [[5l0 - hm-VCL tail domain (mutant)<br /> | ||
| - | **[[5l0c]], [[5l0d]] - hm-VCL tail domain + lipid<br /> | ||
| - | **[[5l0g]], [[5l0h]] - hm-VCL tail domain (mutant) + lipid<br /> | ||
| - | **[[3jbk]] – hm-VCL tail domain + actin – Cryo-EM<br /> | ||
| - | **[[3rf3]] - hm-VCL + invasin IPAA<br /> | ||
| - | **[[3s90]] - hm-VCL head domain + mTalin-1 peptide<br /> | ||
| - | **[[4dj9]] - hm-VCL head domain + hTalin-1 peptide <br /> | ||
| - | **[[3tj5]] - hm-VCL head domain + Sca-family protein peptide<br /> | ||
| - | **[[3tj6]] - hm-VCL head domain + protein Ps 120 peptide<br /> | ||
| - | **[[4ehp]] - hm-VCL head domain + catenin α-1 residues 277-382<br /> | ||
| - | **[[3vf0]] – hm-VCL residues 856-1134 + ribonucleoprotein PTB-binding<br /> | ||
| - | **[[2gdc]] – cm-VCL Vd1+SfInvasin C-terminal <br /> | ||
| - | **[[1xwj]] - cm-VCL Vd1+cTalin VBS3<br /> | ||
| - | **[[1zvz]], [[1zw2]], [[1zw3]], [[1u6h]] - cm-VCL Vd1+cTalin rod<br /> | ||
| - | **[[1st6]] – cm-VCL<br /> | ||
| - | **[[4e17]], [[4e18]] - cm-VCL Vd1 + catenin α-1 VCL-binding domain | ||
| - | }} | ||
==References== | ==References== | ||
<references /> | <references /> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
*Created with the participation of [[User:Susan Craig|Susan Craig]]. | *Created with the participation of [[User:Susan Craig|Susan Craig]]. | ||
Current revision
| |||||||||||
- Created with the participation of Susan Craig.
