5eal

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(New page: ==Crystal structure of human WDR5 in complex with compound 9h== <StructureSection load='5eal' size='340' side='right' caption='5eal, resolution 1.80&Aring;' scene=''> =...)
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==Crystal structure of human WDR5 in complex with compound 9h==
==Crystal structure of human WDR5 in complex with compound 9h==
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<StructureSection load='5eal' size='340' side='right' caption='[[5eal]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5eal' size='340' side='right'caption='[[5eal]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eal]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EAL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EAL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5ML:3-METHYL-~{N}-[2-(4-METHYLPIPERAZIN-1-YL)-5-QUINOLIN-3-YL-PHENYL]BENZAMIDE'>5ML</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eam|5eam]], [[5eap|5eap]], [[5ear|5ear]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ML:3-METHYL-~{N}-[2-(4-METHYLPIPERAZIN-1-YL)-5-QUINOLIN-3-YL-PHENYL]BENZAMIDE'>5ML</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eal OCA], [http://pdbe.org/5eal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eal RCSB], [http://www.ebi.ac.uk/pdbsum/5eal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eal ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eal OCA], [https://pdbe.org/5eal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eal RCSB], [https://www.ebi.ac.uk/pdbsum/5eal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eal ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: AL-AWAR, R]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: BOLSHAN, Y]]
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[[Category: AL-AWAR R]]
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[[Category: BROWN, P J]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: BOLSHAN Y]]
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[[Category: DOMBROVSKI, L]]
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[[Category: BROWN PJ]]
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[[Category: DONG, A]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M]]
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[[Category: DOMBROVSKI L]]
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[[Category: GETLIK, M]]
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[[Category: DONG A]]
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[[Category: PODA, G]]
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[[Category: Edwards AM]]
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[[Category: SCHAPIRA, M]]
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[[Category: GETLIK M]]
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[[Category: SENISTERRA, G]]
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[[Category: PODA G]]
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[[Category: Structural genomic]]
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[[Category: SCHAPIRA M]]
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[[Category: SMIL, D]]
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[[Category: SENISTERRA G]]
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[[Category: VEDADI, M]]
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[[Category: SMIL D]]
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[[Category: WALKER, J R]]
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[[Category: VEDADI M]]
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[[Category: WU, H]]
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[[Category: WALKER JR]]
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[[Category: Compound 9h]]
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[[Category: WU H]]
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[[Category: Sgc]]
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[[Category: Transcription-transcription inhibitor complex]]
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[[Category: Wdr5]]
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Current revision

Crystal structure of human WDR5 in complex with compound 9h

PDB ID 5eal

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