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5ml9

From Proteopedia

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(New page: '''Unreleased structure''' The entry 5ml9 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures)
Current revision (07:26, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5ml9 is ON HOLD until Paper Publication
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==Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.==
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<StructureSection load='5ml9' size='340' side='right'caption='[[5ml9]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ml9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ML9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ML9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ml9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ml9 OCA], [https://pdbe.org/5ml9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ml9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ml9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ml9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23006327</ref> <ref>PMID:8608639</ref> <ref>PMID:8609432</ref> <ref>PMID:8874200</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN] Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.<ref>PMID:21768335</ref> <ref>PMID:22023369</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Baxter EW]]
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[[Category: Fishwick CWG]]
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[[Category: Foster RJ]]
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[[Category: Goldman A]]
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[[Category: Harris SA]]
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[[Category: McPherson MJ]]
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[[Category: Morgan AW]]
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[[Category: Nettleship JE]]
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[[Category: Owen RL]]
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[[Category: Owens RJ]]
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[[Category: Robinson JI]]
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[[Category: Thomsen M]]
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[[Category: Tiede C]]
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[[Category: Tomlinson DC]]
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[[Category: Waterhouse MP]]
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[[Category: Win SJ]]

Current revision

Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.

PDB ID 5ml9

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