Poliovirus receptor-related protein
From Proteopedia
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- | <StructureSection load=' | + | <StructureSection load='' size='450' side='right' caption='Poliovirus receptor-related protein 1 (green) complex with herpes virus envelope glycoprotein (magenta) (PDB code [[4myw]])' scene='74/748856/Cv/1' pspeed='8'> |
== Function == | == Function == | ||
- | '''Poliovirus receptor-related protein''' (PVRP) or '''Nectin''' are membrane glycoproteins belonging to the immunoglobulin family | + | '''Poliovirus receptor-related protein''' (PVRP) or '''Nectin''' are membrane glycoproteins belonging to the immunoglobulin family.<br /> |
*'''PVRP-1''' mediates Ca+2-independent cell adhesion<ref>PMID:09616127</ref>.<br /> | *'''PVRP-1''' mediates Ca+2-independent cell adhesion<ref>PMID:09616127</ref>.<br /> | ||
- | *'''PVRP-2''' and '''PVRP-3''' are components of the adherens junction.<br /> | + | *'''PVRP-2''' and '''PVRP-3''' are components of the adherens junction<ref>PMID:9845526</ref>.<br /> |
*'''PVRP-4''' binds PVRP-1.<br /> | *'''PVRP-4''' binds PVRP-1.<br /> | ||
== Relevance == | == Relevance == | ||
PVRP-4 is involved in tumor cell migration. | PVRP-4 is involved in tumor cell migration. | ||
- | |||
== Structural highlights == | == Structural highlights == | ||
- | + | *<scene name='74/748856/Cv/4'>Poliovirus receptor-related protein 1 interactions with herpes virus envelope glycoprotein</scene>. (PDB code [[4myw]]) | |
- | + | ||
- | + | ||
</StructureSection> | </StructureSection> | ||
==3D structures of poliovirus receptor-related protein== | ==3D structures of poliovirus receptor-related protein== | ||
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**[[4myw]], [[3u82]], [[3sku]] – hPVRP1 + envelope glycoprotein D – human<br /> | **[[4myw]], [[3u82]], [[3sku]] – hPVRP1 + envelope glycoprotein D – human<br /> | ||
+ | **[[5x5w]] – PVRP1 domain D1 + glycoprotein D - pig<br /> | ||
**[[4fmf]], [[3u83]], [[3alp]] – hPVRP1 domains D1-D3 <br /> | **[[4fmf]], [[3u83]], [[3alp]] – hPVRP1 domains D1-D3 <br /> | ||
+ | **[[5b21]] – mPVRP1 domain D1 - mouse<br /> | ||
**[[2l7j]] – hPVRP1 domain D3 - NMR<br /> | **[[2l7j]] – hPVRP1 domain D3 - NMR<br /> | ||
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**[[4hza]], [[4dfh]], [[3r0n]] – hPVRP2 domain D1<br /> | **[[4hza]], [[4dfh]], [[3r0n]] – hPVRP2 domain D1<br /> | ||
**[[4dfi]] – hPVRP2 domain D1 (mutant)<br /> | **[[4dfi]] – hPVRP2 domain D1 (mutant)<br /> | ||
- | **[[4fmk]], [[4fn0]] – mPVRP2 domains D1-D2 | + | **[[5v52]] – hPVRP2 domain D1 + TIGIT<br /> |
+ | **[[4fmk]], [[4fn0]] – mPVRP2 domains D1-D2 <br /> | ||
**[[4fs0]] – mPVRP2 domains D1-D2 (mutant) <br /> | **[[4fs0]] – mPVRP2 domains D1-D2 (mutant) <br /> | ||
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**[[4fom]] – hPVRP3 domains D1-D3 <br /> | **[[4fom]] – hPVRP3 domains D1-D3 <br /> | ||
+ | **[[5b22]] – mPVRP3 domains D1-D2 <br /> | ||
* Poliovirus receptor-related protein 4 | * Poliovirus receptor-related protein 4 | ||
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== References == | == References == | ||
<references/> | <references/> | ||
+ | [[Category:Topic Page]] |
Current revision
|
3D structures of poliovirus receptor-related protein
Updated on 08-August-2019
References
- ↑ Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science. 1998 Jun 5;280(5369):1618-20. PMID:9616127
- ↑ Lopez M, Aoubala M, Jordier F, Isnardon D, Gomez S, Dubreuil P. The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. Blood. 1998 Dec 15;92(12):4602-11. PMID:9845526