Thrombospondin
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Human TSP-1 Nterminal complex with Arixtra heparin (PDB code [[1za4]])' scene='74/748873/Cv/3'> |
== Function == | == Function == | ||
| - | Thrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues<ref>PMID:9304800</ref>. | + | '''Thrombospondin''' (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues<ref>PMID:9304800</ref>. |
== Relevance == | == Relevance == | ||
TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments<ref>PMID:22553494</ref>. | TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments<ref>PMID:22553494</ref>. | ||
| - | == Structural highlights == | ||
| + | == Disease == | ||
| + | TSP-2 mutation is associated with coronary artery disease<ref>PMID:18499674</ref>. | ||
| + | |||
| + | == Structural highlights == | ||
| + | The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The <scene name='74/748873/Cv/4'>arginine and lysine side chains of the N-terminal interact with the heparin sulfate groups</scene><ref>PMID:16407063</ref>. | ||
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| + | |||
| + | *Thrombospondin-1 | ||
| + | |||
| + | **[[1ux6]] – hTSP-1 C-terminal (mutant) 831-1170 + Ca - human<br /> | ||
| + | **[[1lsl]], [[3r6b]] – hTSP-1 repeats 2-3 434-547<br /> | ||
| + | **[[1z78]], [[2erf]], [[2es3]], [[2ouh]], [[2ouj]] – hTSP-1 N-terminal 25-233<br /> | ||
| + | **[[7yyk]] – hTSP-1 378-547<br /> | ||
| + | **[[1za4]] – hTSP-1 N-terminal + heparin<br /> | ||
| + | |||
| + | *Thrombospondin-2 | ||
| + | |||
| + | **[[1yo8]] – hTSP-2 C-terminal<br /> | ||
| + | **[[2rhp]] – hTSP-2 signature domain (mutant)<br /> | ||
| + | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D structures of thrombospondin
Updated on 19-August-2024
References
- ↑ Adams JC. Thrombospondin-1. Int J Biochem Cell Biol. 1997 Jun;29(6):861-5. PMID:9304800
- ↑ Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi:, 10.1101/cshperspect.a006627. PMID:22553494 doi:http://dx.doi.org/10.1101/cshperspect.a006627
- ↑ Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008 Jul 18;283(29):20069-76. Epub 2008 May 22. PMID:18499674 doi:10.1074/jbc.M800223200
- ↑ Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J. The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan;14(1):33-42. PMID:16407063 doi:10.1016/j.str.2005.09.017
