Fatty acid-binding protein

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<StructureSection load='1fe3' size='350' side='right' scene='48/487562/Cv/3' caption='Human brain-type fatty acid-binding protein complex with oleate (PDB code [[1fe3]]) '>
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<StructureSection load='1fe3' size='350' side='right' scene='48/487562/Cv/4' caption='Human brain-type fatty acid-binding protein complex with oleate (PDB code [[1fe3]]) '>
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'''Fatty acid-binding protein''' (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells<ref>PMID:16424607</ref>. Various FABS differ in their tissue expression. '''IFABP''' is intestinal; '''HFABP''' is heart-type; '''BFABP''' is brain-type; '''LFABP''' is liver-type; '''AFABP''' is adipocyte; '''LMDABP''' is from flight muscle; '''TFABP''' is from testis.
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'''Fatty acid-binding protein''' (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells<ref>PMID:16424607</ref>. Various FABS differ in their tissue expression.
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*'''IFABP''' is intestinal;
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*'''HFABP''' is heart-type;
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*'''BFABP''' is brain-type;
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*'''LFABP''' is liver-type;
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*'''AFABP''' is adipocyte;
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*'''LMDABP''' is from flight muscle;
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*'''TFABP''' is from testis.
== Relevance ==
== Relevance ==
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== Structural insights ==
== Structural insights ==
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The <scene name='48/487562/Cv/2'>FABP active site binds fatty acids</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}})<ref>PMID:10854433</ref>.
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The <scene name='48/487562/Cv/5'>FABP active site binds fatty acids</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}})<ref>PMID:10854433</ref>.
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</StructureSection>
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==3D structures of fatty acid-binding protein==
==3D structures of fatty acid-binding protein==
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[[Fatty acid-binding protein 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Intestinal fatty acid-binding protein
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**[[1ael]], [[1a57]], [[1sa8]] - rIFABP – rat – NMR<BR />
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**[[1t8v]] - rIFABP (mutant) – NMR<BR />
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**[[1ifb]], [[1ifc]] - rIFABP <br />
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**[[1dc9]] - rIFABP (mutant)<br />
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**[[1kzw]], [[3ifb]] - hIFABP – human – NMR<BR />
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**[[1kzx]] - hIFABP (mutant) – NMR<BR />
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*''Intestinal fatty acid-binding protein binary complex''
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**[[3akm]], [[2mo5]] - hIFABP + fatty acid analog<br />
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**[[2mji]] - hIFABP + ketorolac - NMR<br />
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**[[3akn]], [[1icm]], [[1icn]], [[2ifb]] - rIFABP + fatty acid analog<br />
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**[[1ure]] - rIFABP + palmitate – NMR<BR />
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*Epidermal fatty acid-binding protein
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**[[1b56]], [[1jjj]], [[4lkp]] - hEFABP <br />
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**[[4azr]], [[4lkt]] - hEFABP + fatty acid<br />
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**[[4azn]], [[4azo]] - mEFABP <br />
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**[[4azp]], [[4azq]] - mEFABP + fatty acid<br />
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**[[4azm]] - hEFABP + inhibitor<br />
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*Heart-type fatty acid-binding protein
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**[[1g5w]] - hHFABP – NMR<BR />
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**[[3rsw]], [[5ce4]] – hHFABP<br />
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**[[3wbg]] – hHFABP + sulfonate derivative<br />
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**[[5hz9]] – hHFABP + inhibitor<br />
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**[[3wvm]], [[4tjz]], [[4tkb]], [[4tkh]], [[4tkj]], [[4wbk]], [[3wxq]] - hHFABP + fatty acid<br />
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**[[1bwy]] – HFABP – bovine<br />
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**[[5d8j]] – HFABP + Fab – mouse<br />
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*Brain-type fatty acid-binding protein
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**[[1fdq]], [[1jjx]] - hBFABP<br />
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**[[1fe3]] - hBFABP + oleate<br />
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*Liver-type fatty acid-binding protein
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**[[1p6p]] - LFABP – toad<br />
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**[[1tvq]], [[1mvg]] - cLFABP – chicken<br />
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**[[1zry]] - cLFABP - NMR<BR />
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**[[2f73]], [[3stn]], [[3b2h]], [[3b2i]], [[3b2j]], [[3b2k]], [[3b2l]], [[3vg2]], [[3vg3]], [[3vg4]], [[3vg5]], [[3vg6]], [[3vg7]] - hLFABP<br />
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**[[2py1]], [[2l67]], [[2l68]] - hLFABP – NMR<BR />
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**[[2ju3]], [[2ju7]] - rLFABP – NMR<BR />
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**[[2ft9]] – AmLFABP - ''Ambystoma mexicanum''
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*''Liver-type fatty acid-binding protein binary complex''
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**[[3stk]], [[3stm]] - hLFABP + palmitate<br />
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**[[2lkk]] - hLFABP + oleate – NMR<br />
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**[[2ju8]] - rLFABP + oleate – NMR<BR />
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**[[1lfo]] - rLFABP + oleate<br />
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**[[1tw4]], [[2jn3]], [[2lfo]] - cLFABP + cholate<br />
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**[[2jn3]] - cLFABP + chenodeoxycholate<br />
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**[[2k62]] - cLFABP + bile acid-based Gd chelate<br />
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**[[2ftb]] - AmLFABP + oleate<br />
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**[[2qo4]] – zLFABP + cholate – zebrafish<br />
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**[[2qo5]], [[2qo6]] – zLFABP (mutant) + cholate <br />
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*Adipocyte fatty acid-binding protein
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**[[1tou]], [[2hnx]], [[3q6l]], [[3rzy]] - hAFABP<br />
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**[[1lib]], [[1alb]] – mAFABP<br />
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**[[1g7n]], [[1ab0]], [[1acd]] - mAFABP (mutant) <br />
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**[[1tow]] - hAFABP + carbazole butanoic acid<br />
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**[[2nnq]], [[3fr2]], [[3fr4]], [[3fr5]], [[5hz6]], [[5hz8]], [[5d45]], [[5d47]], [[5d48]], [[5d4a]], [[5edb]], [[5edc]], [[4nns]], [[4nnt]] - hAFABP + inhibitor<br />
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**[[3p6c]] - hAFABP + citrate<br />
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**[[3p6d]], [[3p6e]] - hAFABP + propionate derivative<br />
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**[[3p6f]] - hAFABP + phenyl-butyrate<br />
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**[[3p6g]], [[3p6h]] - hAFABP + ibuprofen<br />
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**[[2qm9]] - mAFABP + troglitazone <br />
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**[[2q9s]], [[1lid]], [[1lie]], [[1lif]], [[1adl]] - mAFABP + fatty acid<br />
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**[[1g74]] - mAFABP (mutant) + fatty acid <br />
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**[[3hk1]], [[3js1]], [[3jsq]] - mAFABP + inhibitor<br />
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**[[1lic]], [[2ans]] – mAFABP + sulfonic acid derivative<br />
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**[[1a18]] - mAFABP + phenanthroline <br />
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**[[1a2d]] - mAFABP + pyridoxamine <br />
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**[[5c0n]] - mAFABP + Fab <br />
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*Flight muscle fatty acid-binding protein
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**[[2flj]], [[1ftp]] - LMFABP – locust
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*Muscle fatty acid-binding protein
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**[[2hmb]] – hMFABP <br />
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**[[1hmr]], [[1hms]], [[1hmt]] – hMFABP + fatty acid<br />
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*Testis fatty acid-binding protein
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**[[4a60]] - hTFABP
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*Ileal bile acid-binding protein
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**[[3elx]] – zIBABP <br />
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**[[3elz]], [[3em0]] – zIBABP + cholate<br />
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*Other fatty acid-binding protein
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**[[2poa]] - SmFABP (mutant) - ''Schistosoma mansoni'' – NMR<BR />
 
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**[[1mdc]] – FABP – tobacco hornworm<br />
 
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**[[4jgx]] - FABP – ''Yarrowia lipolytica''<br />
 
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**[[1vyf]], [[1vyg]] – SmFABP + fatty acid<br />
 
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**[[3w9k]] – FABP + fatty acid – ''Sulfolobus tokodaii''<br />
 
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**[[2n93]] – FABP – ''Luciola cerata'' - NMR<br />
 
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**[[5bvq]] – PpFABP – ''Pygoscelis papua'' <br />
 
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**[[5bvs]], [[5bvt]] – PpFABP + fatty acid <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human brain-type fatty acid-binding protein complex with oleate (PDB code 1fe3)

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References

  1. ↑ Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet. 2006;47(1):39-48. PMID:16424607 doi:http://dx.doi.org/10.1007/BF03194597
  2. ↑ Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000 Sep 1;275(35):27045-54. PMID:10854433 doi:10.1074/jbc.M003001200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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