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1gyb

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==N77Y point mutant of yNTF2 bound to FxFG nucleoporin repeat==
==N77Y point mutant of yNTF2 bound to FxFG nucleoporin repeat==
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<StructureSection load='1gyb' size='340' side='right' caption='[[1gyb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1gyb' size='340' side='right'caption='[[1gyb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1gyb]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1gyb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gy5|1gy5]], [[1gy6|1gy6]], [[1gy7|1gy7]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyb OCA], [http://pdbe.org/1gyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gyb RCSB], [http://www.ebi.ac.uk/pdbsum/1gyb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyb OCA], [https://pdbe.org/1gyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyb RCSB], [https://www.ebi.ac.uk/pdbsum/1gyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NTF2_YEAST NTF2_YEAST]] Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. In vitro, the NTF2-Ran-GDP association, in the presence of GTP, triggers dissociation of the karyopherin alpha-beta complex, allowing nuclear translocation of karyopherin alpha and the NLS substrate.
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[https://www.uniprot.org/uniprot/NTF2_YEAST NTF2_YEAST] Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. In vitro, the NTF2-Ran-GDP association, in the presence of GTP, triggers dissociation of the karyopherin alpha-beta complex, allowing nuclear translocation of karyopherin alpha and the NLS substrate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyb_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyb_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Nucleoporin|Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bayliss, R]]
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[[Category: Large Structures]]
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[[Category: Stewart, M]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Nuclear transport]]
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[[Category: Synthetic construct]]
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[[Category: Bayliss R]]
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[[Category: Stewart M]]

Current revision

N77Y point mutant of yNTF2 bound to FxFG nucleoporin repeat

PDB ID 1gyb

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