4qbj

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==Crystal structure of N-myristoyl transferase from Aspergillus fumigatus complexed with a synthetic inhibitor==
==Crystal structure of N-myristoyl transferase from Aspergillus fumigatus complexed with a synthetic inhibitor==
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<StructureSection load='4qbj' size='340' side='right' caption='[[4qbj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4qbj' size='340' side='right'caption='[[4qbj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qbj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QBJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qbj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus_Af293 Aspergillus fumigatus Af293]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QBJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XQ:3-[[3-METHYL-2-[[2,3,4-TRIS(FLUORANYL)PHENOXY]METHYL]-1-BENZOFURAN-4-YL]OXY]-N-(PYRIDIN-3-YLMETHYL)PROPAN-1-AMINE'>2XQ</scene>, <scene name='pdbligand=NHM:S-(2-OXO)PENTADECYLCOA'>NHM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XQ:3-[[3-METHYL-2-[[2,3,4-TRIS(FLUORANYL)PHENOXY]METHYL]-1-BENZOFURAN-4-YL]OXY]-N-(PYRIDIN-3-YLMETHYL)PROPAN-1-AMINE'>2XQ</scene>, <scene name='pdbligand=NHM:S-(2-OXO)PENTADECYLCOA'>NHM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbj OCA], [http://pdbe.org/4qbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qbj RCSB], [http://www.ebi.ac.uk/pdbsum/4qbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qbj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbj OCA], [https://pdbe.org/4qbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qbj RCSB], [https://www.ebi.ac.uk/pdbsum/4qbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qbj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
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[https://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Aspergillus fumigatus Af293]]
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[[Category: Shimada, T]]
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[[Category: Large Structures]]
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[[Category: Suzuki, M]]
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[[Category: Shimada T]]
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[[Category: Myristate translocation]]
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[[Category: Suzuki M]]
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[[Category: Myristoyl-coa]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of N-myristoyl transferase from Aspergillus fumigatus complexed with a synthetic inhibitor

PDB ID 4qbj

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