5m1z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN hydroximolactone INHIBITOR== | |
| + | <StructureSection load='5m1z' size='340' side='right'caption='[[5m1z]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5m1z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M1Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LW:(2~{Z},3~{R},4~{R},5~{S})-2-HYDROXYIMINO-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL'>6LW</scene>, <scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m1z OCA], [https://pdbe.org/5m1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m1z RCSB], [https://www.ebi.ac.uk/pdbsum/5m1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m1z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B8ZY56_GIBZA B8ZY56_GIBZA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The synthesis of potent inhibitors of GH93 arabinanases as well as a synthesis of a chromogenic substrate to measure GH93 arabinanase activity is described. An insight into the reasons behind the potency of the inhibitors was gained through X-ray crystallographic analysis using the arabinanase Arb93A from Fusarium graminearum. These compounds lay a foundation for future inhibitor development as well as for the use of the chromogenic substrate in biochemical studies of GH93 arabinanases. | ||
| - | + | Exploiting sp2-hybridization in the development of potent 1,5-a-L-arabinanase inhibitors.,Coyle T, Debowski A, Varrot A, Stubbs KA Chembiochem. 2017 Mar 7. doi: 10.1002/cbic.201700073. PMID:28266777<ref>PMID:28266777</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Varrot | + | <div class="pdbe-citations 5m1z" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fusarium graminearum]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Varrot A]] | ||
Current revision
STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN hydroximolactone INHIBITOR
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