5u2u

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'''Unreleased structure'''
 
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The entry 5u2u is ON HOLD
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==Crystal structure of the Hsp104 N-terminal domain from Saccharomyces cerevisiae==
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<StructureSection load='5u2u' size='340' side='right'caption='[[5u2u]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5u2u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U2U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.541&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u2u OCA], [https://pdbe.org/5u2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u2u RCSB], [https://www.ebi.ac.uk/pdbsum/5u2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u2u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS104_YEAST HS104_YEAST] Required, in concert with Hsp40 (YDJ1) and Hsp70 (SSA1) and small Hsps (HSP26), for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by components of the Hsp70/Hsp40 chaperone system. Substrate binding is ATP-dependent, and release of bound polypeptide is triggered by ATP hydrolysis. Also responsible for the maintenance of prions by dissociating prion fibrils into smaller oligomers, thereby producing transmissible seeds that can infect daughter cells during mitosis and meiosis. Loss of HSP104 can cure yeast cells of the prions [PSI+], [URE3] and [PIN+]. Excess HSP104 can also specifically cure cells of [PSI+].<ref>PMID:10678178</ref> <ref>PMID:11073991</ref> <ref>PMID:11375656</ref> <ref>PMID:11442834</ref> <ref>PMID:12101251</ref> <ref>PMID:14507919</ref> <ref>PMID:15128736</ref> <ref>PMID:15155912</ref> <ref>PMID:15843375</ref> <ref>PMID:15845535</ref> <ref>PMID:1600951</ref> <ref>PMID:16570324</ref> <ref>PMID:16885031</ref> <ref>PMID:17253904</ref> <ref>PMID:17259993</ref> <ref>PMID:17367387</ref> <ref>PMID:17543332</ref> <ref>PMID:18312264</ref> <ref>PMID:2188365</ref> <ref>PMID:7754373</ref> <ref>PMID:7984243</ref> <ref>PMID:8407824</ref> <ref>PMID:8643570</ref> <ref>PMID:9534180</ref> <ref>PMID:9674429</ref>
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Authors: Wang, P., Li, J., Sha, B.
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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Description: Crystal structure of the Hsp104 N-terminal domain from Saccharomyces cerevisiae
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Sha, B]]
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__TOC__
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[[Category: Li, J]]
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</StructureSection>
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[[Category: Wang, P]]
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Li J]]
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[[Category: Sha B]]
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[[Category: Wang P]]

Current revision

Crystal structure of the Hsp104 N-terminal domain from Saccharomyces cerevisiae

PDB ID 5u2u

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